β-lactam antibiotic resistance:: a current structural perspective

被引：279
作者：
Wilke, MS
Lovering, AL
Strynadka, NCJ
机构：
[1] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada
[2] Univ British Columbia, Ctr Blood Res, Vancouver, BC V6T 1Z3, Canada
来源：
CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 05期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1016/j.mib.2005.08.016
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bacterial resistance to beta-lactam antibiotics can be achieved by any of three strategies: the production of beta-lactam-hydrolyzing beta-lactamase enzymes, the utilization of beta-lactam-insensitive cell wall trans peptidases, and the active expulsion of beta-lactam molecules from Gram-negative cells by way of efflux pumps. In recent years, structural biology has contributed significantly to the understanding of these processes and should prove invaluable in the design of drugs to combat beta-lactam resistance in the future.
引用
收藏
页码：525 / 533
页数：9
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