Papain-catalyzed aldol reaction for the synthesis of trifluoromethyl carbinol derivatives

被引：15

作者：

Guo, Jun-Tao ^{[1
]}

Xiang, Yang ^{[1
]}

Guan, Zhi ^{[1
]}

He, Yan-Hong ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2016年 / 131卷

基金：

中国国家自然科学基金;

关键词：

Papain; Aldol reaction; Trifluoromethyl carbinol derivatives; Enzyme catalytic promiscuity; DYNAMIC KINETIC RESOLUTION; BOND-FORMING REACTIONS; DIELS-ALDER REACTION; ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; TERTIARY ALCOHOLS; AROMATIC KETONES; PRIMARY AMINE; ENANTIOSELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS;

D O I：

10.1016/j.molcatb.2016.05.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Papain from Carica papaya demonstrated catalytic promiscuity was first discovered to catalyze the synthesis of trifluoromethyl carbinol derivatives via aldol reaction between alpha,alpha,alpha-trifluoromethyl ketones and aliphatic ketones in a mixed solvent of DMF and water. The best results of the corresponding aldol products with up to 99% yield and 30% ee were achieved. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：55 / 64

页数：10

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