An efficient catalytic method for the Friedlander annulation mediated by peptide coupling agent propylphosphonic anhydride (T3P®)

被引：25

作者：

Augustine, John Kallikat ^{[1
]}

Bombrun, Agnes ^{[2
]}

Venkatachaliah, Srinivasa ^{[1
]}

机构：

[1] Syngene Int Ltd, Bangalore 560099, Karnataka, India

[2] Merck Serono SA, CH-1202 Geneva, Switzerland

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 50期

关键词：

Friedlander annulation; Propylphosphonic anhydride; Quinolines; Catalytic; Microwave irradiation; PHOSPHONIC ACID ANHYDRIDE; QUINOLINE; QUINAZOLINE; DERIVATIVES; CONVENIENT; PROMOTER; SERIES; MILD;

D O I：

10.1016/j.tetlet.2011.10.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have demonstrated the utilization of T3P, a mild and low toxic peptide coupling agent, as a promoter and water scavenger in the Friedlander annulation, and thus introduced a highly efficient catalytic process to access carbocyclic and heterocyclic fused quinolines under microwave irradiation or a conventional heating technique. The reaction conditions are sufficiently mild to tolerate the acid and base sensitive functional groups that can serve as levers for further extension of the quinoline products. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6814 / 6818

页数：5

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