Effect of a topical formulation containing Calophyllum brasiliense Camb. extract on cutaneous wound healing in rats

被引：5
作者：
Lordani, T. V. A. [1 ]
Brenzan, M. A. [2 ]
Cortez, L. E. R. [1 ]
Lordani, C. R. F. [3 ]
Honda, P. A. [2 ]
Lonardoni, M. V. C. [4 ]
Cortez, D. A. G. [1 ,2 ]
机构：
[1] Ctr Univ Maringa, CESUMAR, Programa Posgrad Promocao Saude, BR-87050900 Maringa, Parana, Brazil
[2] Univ Estadual Maringa, Dept Farm & Farmacol, Posgrad Ciencias Farmaceut, BR-87020900 Maringa, Parana, Brazil
[3] Fac Assis Gurgacz, Dept Nutr, BR-85806095 Cascavel, PR, Brazil
[4] Univ Estadual Maringa, Posgrad Biociencias & Fisiopatol, BR-87020900 Maringa, Parana, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 10期
关键词：
Calophyllum brasiliense; wound healing; rat; topical treatment; crude extract; COUMARINS; LEAVES; DERIVATIVES; GENUS;
D O I：
10.1080/14786419.2014.956742
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
This study evaluated the wound healing effects of topical application of an emulsion containing the HPLC-standardised extract from Calophyllum brasiliense Cambess (Clusiaceae) leaves in rats. The macroscopic analysis demonstrated that the wounds treated with the C. brasiliense emulsion healed earlier than the wounds treated with emulsion base and Dersani (R). The percentage of wound healing in the group treated with the C. brasiliense emulsion was significantly higher than in the other groups at 7 and 14 days. On day 14, the animals treated with the C. brasiliense emulsion exhibited a 90.67% reduction of the wound areas. The histological evaluation revealed that on day 21, the group treated with the C. brasiliense emulsion exhibited a significant increase in fibroblasts compared with the other groups. Thus, the C. brasiliense emulsion had healing properties in the topical treatment of wounds and accelerated the healing process.
引用
收藏
页码：953 / 957
页数：5
相关论文
共 22 条
  • [11] Efficacy of components from leaves of Calophyllum brasiliense against Leishmania (Leishmania) amazonensis
    Honda, P. A.
    Ferreira, I. C. P.
    Cortez, D. A. G.
    Amado, C. A. B.
    Silveira, T. G. V.
    Brenzan, M. A.
    Lonardoni, M. V. C.
    [J]. PHYTOMEDICINE, 2010, 17 (05) : 333 - 338
  • [12] Honda PA, 2011, Brazil patent, Patent No. [BR200904042-A2, 200904042]
  • [13] Calophyllum genus:: Chemical and pharmacological importance.
    Noldin, Vania Floriani
    Isaias, Daniela Buffon
    Cechinel Filho, Valdir
    [J]. QUIMICA NOVA, 2006, 29 (03): : 549 - 554
  • [14] Cytotoxic and antimicrobial coumarins from Mammea africana
    Ouahouo, BMW
    Azebaze, AGB
    Meyer, M
    Bodo, B
    Fomum, ZT
    Nkengfack, AE
    [J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2004, 98 (07): : 733 - 739
  • [15] Pretto JB, 2004, Z NATURFORSCH C, V59, P657
  • [16] Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense
    Reyes-Chilpa, R
    Estrada-Muñiz, E
    Apan, TR
    Amekraz, B
    Aumelas, A
    Jankowski, CK
    Vázquez-Torres, M
    [J]. LIFE SCIENCES, 2004, 75 (13) : 1635 - 1647
  • [17] Cellular and molecular facets of keratinocyte reepithelization during wound healing
    Santoro, MM
    Gaudino, G
    [J]. EXPERIMENTAL CELL RESEARCH, 2005, 304 (01) : 274 - 286
  • [18] Santos Manoel Francisco da Silva, 2006, Acta Cir. Bras., V21, P2, DOI 10.1590/S0102-86502006000900002
  • [19] Influence of Terminalia chebula on dermal wound healing in rats
    Suguna, L
    Singh, S
    Sivakumar, P
    Sampath, P
    Chandrakasan, G
    [J]. PHYTOTHERAPY RESEARCH, 2002, 16 (03) : 227 - 231
  • [20] Intramuscular and topical treatment of cutaneous leishmaniasis lesions in mice infected with Leishmania amazonensis using coumarin (-) mammea A/BB
    Tiuman, Tatiana Shioji
    Brenzan, Mislaine Adriana
    Ueda-Nakamura, Tania
    Dias Filho, Benedito Prado
    Garcia Cortez, Diogenes Aparicio
    Nakamura, Celso Vataru
    [J]. PHYTOMEDICINE, 2012, 19 (13) : 1196 - 1199
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