Effect of a topical formulation containing Calophyllum brasiliense Camb. extract on cutaneous wound healing in rats

被引：5
作者：
Lordani, T. V. A. [1 ]
Brenzan, M. A. [2 ]
Cortez, L. E. R. [1 ]
Lordani, C. R. F. [3 ]
Honda, P. A. [2 ]
Lonardoni, M. V. C. [4 ]
Cortez, D. A. G. [1 ,2 ]
机构：
[1] Ctr Univ Maringa, CESUMAR, Programa Posgrad Promocao Saude, BR-87050900 Maringa, Parana, Brazil
[2] Univ Estadual Maringa, Dept Farm & Farmacol, Posgrad Ciencias Farmaceut, BR-87020900 Maringa, Parana, Brazil
[3] Fac Assis Gurgacz, Dept Nutr, BR-85806095 Cascavel, PR, Brazil
[4] Univ Estadual Maringa, Posgrad Biociencias & Fisiopatol, BR-87020900 Maringa, Parana, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 10期
关键词：
Calophyllum brasiliense; wound healing; rat; topical treatment; crude extract; COUMARINS; LEAVES; DERIVATIVES; GENUS;
D O I：
10.1080/14786419.2014.956742
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
This study evaluated the wound healing effects of topical application of an emulsion containing the HPLC-standardised extract from Calophyllum brasiliense Cambess (Clusiaceae) leaves in rats. The macroscopic analysis demonstrated that the wounds treated with the C. brasiliense emulsion healed earlier than the wounds treated with emulsion base and Dersani (R). The percentage of wound healing in the group treated with the C. brasiliense emulsion was significantly higher than in the other groups at 7 and 14 days. On day 14, the animals treated with the C. brasiliense emulsion exhibited a 90.67% reduction of the wound areas. The histological evaluation revealed that on day 21, the group treated with the C. brasiliense emulsion exhibited a significant increase in fibroblasts compared with the other groups. Thus, the C. brasiliense emulsion had healing properties in the topical treatment of wounds and accelerated the healing process.
引用
收藏
页码：953 / 957
页数：5
相关论文
共 22 条
  • [1] [Anonymous], 2009, INT J APPL RES NATUR
  • [2] Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat
    Asadi, Sayyed Yazdan
    Parsaei, Pouya
    Karimi, Mehrdad
    Ezzati, Sareh
    Zamiri, Alaleh
    Mohammadizadeh, Fereshteh
    Rafieian-kopaei, Mahmoud
    [J]. INTERNATIONAL JOURNAL OF SURGERY, 2013, 11 (04) : 332 - 337
  • [3] Castelo Branco Neto Manoel Lages, 2006, Acta Cir. Bras., V21, P17, DOI 10.1590/S0102-86502006000800004
  • [4] Effects of (-) mammea A/BB isolated from Calophyllum brasiliense leaves and derivatives on mitochondrial membrane of Leishmania amazonensis
    Brenzan, M. A.
    Santos, A. O.
    Nakamura, C. V.
    Dias Filho, B. P.
    Ueda-Nakamura, T.
    Young, M. C. M.
    Correa, A. G.
    Alvim Junior, J.
    Morgado-Diaz, J. A.
    Cortez, D. A. G.
    [J]. PHYTOMEDICINE, 2012, 19 (3-4) : 223 - 230
  • [5] Activity of extracts and coumarins from the leaves of Calophyllum brasiliense on Leishmania braziliensis
    Brenzan, Mislaine Adriana
    Piloto Ferreira, Izabel Cristina
    Campana Lonardoni, Maria Valdrinez
    Honda, Paula Akemi
    Rodrigues Filho, Edson
    Nakamura, Celso Vataru
    Dias Filho, Benedito Prado
    Ueda-Nakamura, Tania
    Garcia Cortez, Diogenes Aparicio
    [J]. PHARMACEUTICAL BIOLOGY, 2008, 46 (06) : 380 - 386
  • [6] Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis
    Brenzan, Mislaine Adriana
    Nakamura, Celso Vataru
    Dias Filho, Benedito Prado
    Ueda-Nakamura, Tania
    Young, Maria Claudia M.
    Garcia Cortez, Diogenes Aparicio
    [J]. PARASITOLOGY RESEARCH, 2007, 101 (03) : 715 - 722
  • [7] Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis
    Brenzan, Mislaine Adriana
    Nakamura, Celso Vataru
    Dias Filho, Benedito Prado
    Ueda-Nakamura, Tania
    Young, Maria Claudia M.
    Correa, Arlene Goncalves
    Junior, Joel Alvirn
    dos Santos, Adriana Oliveira
    Garcia Cortez, Diogenes Aparicio
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (09) : 651 - 658
  • [8] Chemical and Pharmacological Aspects of the Genus Calophyllum
    Cechinel Filho, Valdir
    Meyre-Silva, Christiane
    Niero, Rivaldo
    [J]. CHEMISTRY & BIODIVERSITY, 2009, 6 (03) : 313 - 327
  • [9] THE USE OF FATTY ACIDS IN WOUND CARE: AN INTEGRATIVE REVIEW OF THE BRAZILIAN LITERATURE
    Ferreira, Adriano Menis
    Vieira de Souza, Bruna Machado
    Rigotti, Marcelo Alessandro
    Dias Loureiro, Marisa Rolan
    [J]. REVISTA DA ESCOLA DE ENFERMAGEM DA USP, 2012, 46 (03) : 752 - 760
  • [10] Garros Inaldo de Castro, 2006, Acta Cir. Bras., V21, P55, DOI 10.1590/S0102-86502006000900009
123