Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19

被引：211

作者：

Kim, Eu Suk ^{[1
]}

Chin, Bum Sik ^{[2
]}

Kang, Chang Kyung ^{[3
]}

Kim, Nam Joong ^{[3
]}

Kang, Yu Min ^{[4
]}

Choi, Jae-Phil ^{[5
]}

Oh, Dong Hyun ^{[5
]}

Kim, Jeong-Han ^{[6
]}

Koh, Boram ^{[7
]}

Kim, Seong Eun ^{[8
]}

Yun, Na Ra ^{[9
]}

Lee, Jae-Hoon ^{[10
]}

Kim, Jin Yong ^{[11
]}

Kim, Yeonjae ^{[2
]}

Bang, Ji Hwan ^{[12
]}

Song, Kyoung-Ho ^{[1
]}

Kim, Hong Bin ^{[1
]}

Chung, Ki-Hyun ^{[13
]}

Oh, Myoung-don ^{[3
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

[2] Natl Med Ctr, Dept Internal Med, Div Infect Dis, Seoul, South Korea

[3] Seoul Natl Univ, Dept Internal Med, Coll Med, 103 Daehak Ro, Seoul 03080, South Korea

[4] Myongji Hosp, Dept Infect Dis, Goyang, South Korea

[5] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea

[6] Armed Forces Capital Hosp, Dept Internal Med, Div Infect Dis, Seongnam, South Korea

[7] Ansung Hosp, Dept Internal Med, Gyeonggi Prov Med Ctr, Anseong, South Korea

[8] Chonnam Natl Univ, Dept Infect Dis, Med Sch, Gwangju, South Korea

[9] Chosun Univ, Coll Med, Dept Internal Med, Gwangju, South Korea

[10] Wonkwang Univ, Dept Internal Med, Sch Med, Iksan, South Korea

[11] Incheon Med Ctr, Dept Internal Med, Div Infect Dis, Incheon, South Korea

[12] Seoul Natl Univ, Div Infect Dis, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul, South Korea

[13] Natl Med Ctr, Dept Pediat, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2020年 / 35卷 / 13期

关键词：

COVID-19; SARS-CoV-2; Viral Pneumonia; Prognosis; Cohort Study; Republic of Korea; VIRAL LOAD; TRANSMISSION; PNEUMONIA; OUTBREAK;

D O I：

10.3346/jkms.2020.35.e142

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. Methods: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. Results: The median age was 40 years (range, 20-73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6 0 /0) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7 0 /0). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5-7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the tipper respiratory tract (URT). Conclusion: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.

引用

页数：12

共 23 条

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