Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats

被引：13

作者：

Takada, S ^{[1
]}

Takahara, S ^{[1
]}

Nishimura, K ^{[1
]}

Ichimaru, N ^{[1
]}

Hongsi, J ^{[1
]}

Kokado, Y ^{[1
]}

Kitamura, M ^{[1
]}

Matsumiya, K ^{[1
]}

Matsumoto, K ^{[1
]}

Nakamura, T ^{[1
]}

Okuyama, A ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Dept Urol, Osaka 5650871, Japan

来源：

TRANSPLANT INTERNATIONAL | 1999年 / 12卷 / 01期

关键词：

hepatocyte growth factor; tacrolimus; renal toxicity; renal regeneration;

D O I：

10.1007/s001470050181

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Renal toxicity is a serious side effect of therapy with tacrolimus (FK506), an immunosuppressive agent administered to renal transplant recipients. We investigated the effect of hepatocyte growth factor (HGF) on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats (SHR). After a right nephrectomy, rats received a continuous perfusion of either HGF in a dose of 5 mu g/kg daily (tacrolimus + HGF group) or normal saline (tacrolimus group) into the left renal artery at a rate of 1 mu l/h for 7 days after surgery. Tacrolimus was injected intramuscularly in a dose of 4 mg/kg daily for 10 days after surgery. HGF significantly inhibited the tacrolimus-induced increase in the serum creatinine (SCr) level (P < 0.05). HGF also prevented the tacrolimus-induced loss in body weight. The bromodeoxyuridine (BrdU) index was significantly higher in kidney specimens from the tacrolimus + HGF group. These findings suggest that HGF induces the regeneration of renal tubular cells and suppresses tacrolimus-induced renal toxicity in SHR.

引用

页码：27 / 32

页数：6

共 23 条

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