A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle - oligonucleotide conjugates

被引：61

作者：

Sharma, Jaswinder ^{[1
]}

Chhabra, Rahul ^{[1
]}

Yan, Hao ^{[1
]}

Liu, Yan ^{[1
]}

机构：

[1] Arizona State Univ, Dept Chem & Biochem, Biodesign Inst, Tempe, AZ 85287 USA

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 18期

关键词：

D O I：

10.1039/b800109j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.

引用

页码：2140 / 2142

页数：3

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