Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study

被引：6

作者：

Moreno-Villanueva, Maria ^{[1
]}

Buerkle, Alexander ^{[1
]}

机构：

[1] Univ Konstanz, Dept Biol, Mol Toxicol Grp, D-78457 Constance, Germany

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2019年 / 177卷

关键词：

Human ageing; Biomarkers; Chronological age; Biological age; Health span; Observational study; Europe; Nutrition; Peripheral blood mononuclear cells; DNA damage; Epigenetics; Oxidative stress; Zinc homeostasis; DNA methyltransferases; Ten-eleven translocation family of 5-mC; hydroxylases; Vaccination; DNA METHYLATION; OXIDATIVE STRESS; POLY(ADP-RIBOSYL)ATION; METALLOTHIONEIN; DAMAGE; EXPRESSION; REPAIR; 5-HYDROXYMETHYLCYTOSINE; HYPERMETHYLATION; POPULATION;

D O I：

10.1016/j.mad.2018.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ageing is a multifactorial process that affects most, if not all, of the body's tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that 'biological age' of a person may be different from 'chronological age'. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological ageing is important for preventing age-associated diseases and extending health span. MARK-AGE, a large-scale European study, aimed at identifying a set of biomarkers which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. But beyond the identification of useful biomarkers, MARK AGE provided new insights in age-associated specific cellular processes, such as DNA methylation, oxidative stress and the regulation of zinc homeostasis.

引用

页码：128 / 134

页数：7

共 68 条

[1] Present and future of anti-ageing epigenetic diets [J].

Bacalini, Maria Giulia ;

Friso, Simonetta ;

Olivieri, Fabiola ;

Pirazzini, Chiara ;

Giuliani, Cristina ;

Capri, Miriam ;

Santoro, Aurelia ;

Franceschi, Claudio ;

Garagnani, Paolo .

MECHANISMS OF AGEING AND DEVELOPMENT, 2014, 136 :101-115

[2] DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines [J].

Bell, Jordana T. ;

Pai, Athma A. ;

Pickrell, Joseph K. ;

Gaffney, Daniel J. ;

Pique-Regi, Roger ;

Degner, Jacob F. ;

Gilad, Yoav ;

Pritchard, Jonathan K. .

GENOME BIOLOGY, 2011, 12 (01)

[3] Oxidative Stress and Antioxidant Defense [J].

Birben, Esra ;

Sahiner, Umit Murat ;

Sackesen, Cansin ;

Erzurum, Serpil ;

Kalayci, Omer .

WORLD ALLERGY ORGANIZATION JOURNAL, 2012, 5 :9-19

[4] Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping [J].

Bock, Christoph ;

Walter, Joern ;

Paulsen, Martina ;

Lengauer, Thomas .

NUCLEIC ACIDS RESEARCH, 2008, 36 (10)

[5] Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and Replication [J].

Breitling, Lutz P. ;

Yang, Rongxi ;

Korn, Bernhard ;

Burwinkel, Barbara ;

Brenner, Hermann .

AMERICAN JOURNAL OF HUMAN GENETICS, 2011, 88 (04) :450-457

[6] MARK-AGE biomarkers of ageing [J].

Buerkle, Alexander ;

Moreno-Villanueva, Maria ;

Bernhard, Juergen ;

Blasco, Maria ;

Zondag, Gerben ;

Hoeijmakers, Jan H. J. ;

Toussaint, Olivier ;

Grubeck-Loebenstein, Beatrix ;

Mocchegiani, Eugenio ;

Collino, Sebastiano ;

Gonos, Efstathios S. ;

Sikora, Ewa ;

Gradinaru, Daniela ;

Dolle, Martijn ;

Salmon, Michel ;

Kristensen, Peter ;

Griffiths, Helen R. ;

Libert, Claude ;

Grune, Tilman ;

Breusing, Nicolle ;

Simm, Andreas ;

Franceschi, Claudio ;

Capri, Miriam ;

Talbot, Duncan ;

Caiafa, Paola ;

Friguet, Bertrand ;

Slagboom, P. Eline ;

Hervonen, Antti ;

Hurme, Mikko ;

Aspinall, Richard .

MECHANISMS OF AGEING AND DEVELOPMENT, 2015, 151 :2-12

[7] Poly(ADP-ribose): PARadigms and PARadoxes [J].

Buerkle, Alexander ;

Virag, Laszlo .

MOLECULAR ASPECTS OF MEDICINE, 2013, 34 (06) :1046-1065

[8] Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2 [J].

Buscarlet, Manuel ;

Tessier, Alain ;

Provost, Sylvie ;

Mollica, Luigina ;

Busque, Lambert .

EXPERIMENTAL HEMATOLOGY, 2016, 44 (11) :1072-1084

[9] Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns [J].

Caiafa, Paola ;

Guastafierro, Tiziana ;

Zampieri, Michele .

FASEB JOURNAL, 2009, 23 (03) :672-678

[10] MARK-AGE population: From the human model to new insights [J].

Capri, Miriam ;

Moreno-Villanueva, Maria ;

Cevenini, Elisa ;

Pini, Elisa ;

Scurti, Maria ;

Borelli, Vincenzo ;

Palmas, Maria Giustina ;

Zoli, Marco ;

Schoen, Christiane ;

Siepelmeyer, Anne ;

Bernhardt, Juergen ;

Fiegl, Simone ;

Zondag, Gerben ;

de Craen, Anton J. M. ;

Hervonen, Antti ;

Hurme, Mikko ;

Sikora, Ewa ;

Gonos, Efstathios S. ;

Voutetakis, Konstantinos ;

Toussaint, Olivier ;

Debacq-Chainiaux, Florence ;

Grubeck-Loebenstein, Beatrix ;

Buerkle, Alexander ;

Franceschi, Claudio .

MECHANISMS OF AGEING AND DEVELOPMENT, 2015, 151 :13-17

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