ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission

被引:87
作者
Alonso Y Adell, Manuel [1 ]
Migliano, Simona M. [1 ]
Teis, David [1 ]
机构
[1] Med Univ Innsbruck, Div Cell Biol, Bioctr, A-6020 Innsbruck, Austria
基金
奥地利科学基金会;
关键词
adaptors; ESCRT-III; membrane remodelling; Vps4; AAA-ATPase; ENDOSOME-ASSOCIATED COMPLEX; PROTEIN-SORTING PATHWAY; MVB VESICLE FORMATION; MULTIVESICULAR-BODY; AAA-ATPASE; STRUCTURAL BASIS; FRONTOTEMPORAL DEMENTIA; EXTRACELLULAR VESICLES; PLASMA-MEMBRANE; SACCHAROMYCES-CEREVISIAE;
D O I
10.1111/febs.13688
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Complex molecular machineries bud, scission and repair cellular membranes. Components of the multi-subunit endosomal sorting complex required for transport (ESCRT) machinery are enlisted when multivesicular bodies are generated, extracellular vesicles are formed, the plasma membrane needs to be repaired, enveloped viruses bud out of host cells, defective nuclear pores have to be cleared, the nuclear envelope must be resealed after mitosis and for final midbody abscission during cytokinesis. While some ESCRT components are only required for specific processes, the assembly of ESCRT-III polymers on target membranes and the action of the AAA-ATPase Vps4 are mandatory for every process. In this review, we summarize the current knowledge of structural and functional features of ESCRT-III/Vps4 assemblies in the growing pantheon of ESCRT-dependent pathways. We describe specific recruitment processes for ESCRT-III to different membranes, which could be useful to selectively inhibit ESCRT function during specific processes, while not affecting other ESCRT-dependent processes. Finally, we speculate how ESCRT-III and Vps4 might function together and highlight how the characterization of their precise spatiotemporal organization will improve our understanding of ESCRT-mediated membrane budding and scission in vivo.
引用
收藏
页码:3288 / 3302
页数:15
相关论文
共 145 条
  • [1] Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation
    Adell, Manuel Alonso Y.
    Vogel, Georg F.
    Pakdel, Mehrshad
    Mueller, Martin
    Lindner, Herbert
    Hess, Michael W.
    Teis, David
    [J]. JOURNAL OF CELL BIOLOGY, 2014, 205 (01) : 33 - 49
  • [2] An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome
    Allison, Rachel
    Lumb, Jennifer H.
    Fassier, Coralie
    Connell, James W.
    Ten Martin, Daniel
    Seaman, Matthew N. J.
    Hazan, Jamile
    Reid, Evan
    [J]. JOURNAL OF CELL BIOLOGY, 2013, 202 (03) : 527 - 543
  • [3] The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
    Babst, M
    Wendland, B
    Estepa, EJ
    Emr, SD
    [J]. EMBO JOURNAL, 1998, 17 (11) : 2982 - 2993
  • [4] Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body
    Babst, M
    Katzmann, DJ
    Snyder, WB
    Wendland, B
    Emr, SD
    [J]. DEVELOPMENTAL CELL, 2002, 3 (02) : 283 - 289
  • [5] A protein's final ESCRT
    Babst, M
    [J]. TRAFFIC, 2005, 6 (01) : 2 - 9
  • [6] ESCRT-III: An endosome-associated heterooligomeric protein complex required for MVB sorting
    Babst, M
    Katzmann, DJ
    Estepa-Sabal, EJ
    Meerloo, T
    Emr, SD
    [J]. DEVELOPMENTAL CELL, 2002, 3 (02) : 271 - 282
  • [7] Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p
    Babst, M
    Sato, TK
    Banta, LM
    Emr, SD
    [J]. EMBO JOURNAL, 1997, 16 (08) : 1820 - 1831
  • [8] Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
    Baietti, Maria Francesca
    Zhang, Zhe
    Mortier, Eva
    Melchior, Aurelie
    Degeest, Gisele
    Geeraerts, Annelies
    Ivarsson, Ylva
    Depoortere, Fabienne
    Coomans, Christien
    Vermeiren, Elke
    Zimmermann, Pascale
    David, Guido
    [J]. NATURE CELL BIOLOGY, 2012, 14 (07) : 677 - 685
  • [9] Structural basis for ESCRT-III protein autoinhibition
    Bajorek, Monika
    Schubert, Heidi L.
    McCullough, John
    Langelier, Charles
    Eckert, Debra M.
    Stubblefield, William-May B.
    Uter, Nathan T.
    Myszka, David G.
    Hill, Christopher P.
    Sundquist, Wesley I.
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (07) : 754 - U95
  • [10] Biochemical Analyses of Human IST1 and Its Function in Cytokinesis
    Bajorek, Monika
    Morita, Eiji
    Skalicky, Jack J.
    Morham, Scott G.
    Babst, Markus
    Sundquist, Wesley I.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (05) : 1360 - 1373