The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

被引：106

作者：

Harding, Simon D. ^{[1
]}

Armstrong, Jane F. ^{[1
]}

Faccenda, Elena ^{[1
]}

Southan, Christopher ^{[1
]}

Alexander, Stephen P. H. ^{[2
]}

Davenport, Anthony P. ^{[3
]}

Pawson, Adam J. ^{[1
]}

Spedding, Michael ^{[4
]}

Davies, Jamie A. ^{[1
]}

机构：

[1] Univ Edinburgh, Deanery Biomed Sci, Edinburgh EH8 9XD, Midlothian, Scotland

[2] Univ Nottingham, Sch Life Sci, Med Sch, Nottingham NG7 2UH, England

[3] Univ Cambridge, Expt Med & Immunotherapeut, Cambridge CB2 0QQ, England

[4] Spedding Res Solut SAS, F-78110 Le Vesinet, France

来源：

NUCLEIC ACIDS RESEARCH | 2022年 / 50卷 / D1期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

RECEPTORS;

D O I：

10.1093/nar/gkab1010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.

引用

页码：D1282 / D1294

页数：13

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