Synthesis and Biological Activity of Chiral Dihydropyrazole: Potential Lead for Drug Design

被引：57

作者：

Liu, X. -H. ^{[1
,2
]}

Ruan, B. -F. ^{[1
]}

Li, J. ^{[2
]}

Chen, F. -H. ^{[2
]}

Song, B. -A. ^{[3
]}

Zhu, H. -L. ^{[1
]}

Bhadury, P. S. ^{[3
]}

Zhao, J. ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China

[3] Guizhou Univ, Educ Minist, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Dihydropyrazole; biological activities; SAR; lead; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMYCOBACTERIAL ACTIVITY; PHARMACOLOGICAL EVALUATION; PYRAZOLINE DERIVATIVES; ANTIVIRAL ACTIVITY; 5-TRIFLUOROMETHYL-4,5-DIHYDRO-1H-PYRAZOLES; 3,4-DIARYLPYRAZOLINES; INHIBITION; MOIETY;

D O I：

10.2174/138955711796355285

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dihydropyrazole, a small bioactive molecule, is a prominent structural motif found in numerous pharmaceutically active compounds. The chiral dihydropyrazole structure has been demonstrated to bear important biological activities such as anticancer, antimicrobial, antimalarial, antinociceptive, antiviral, antitubercular, antiinflammatory, anticonvulsant and steroidal, and can also act as MAO inhibitors, CB1 receptor antagonists and nitric oxide synthase inhibitors. The review describes the latest advances in the synthesis of dihydropyrazole derivatives incorporating physiologically active substances. It is the first attempt at a general and systematic account of the extensive literature data on this subject.

引用

页码：771 / 821

页数：51

共 89 条

[1] Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles [J].

Abdel-Wahab, Bakr F. ;

Abdel-Aziz, Hatem A. ;

Ahmed, Essam M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) :2632-2635

[2] Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides [J].

Abdou, IM ;

Saleh, AM ;

Zohdi, HF .

MOLECULES, 2004, 9 (03) :109-116

[3] Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines [J].

Acharya, Badri Narayan ;

Saraswat, Deepika ;

Tiwari, Mugdha ;

Shrivastava, Asish Kumar ;

Ghorpade, Ramarao ;

Bapna, Saroj ;

Kaushik, Mahabir Parshad .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) :430-438

[4] Antitubercular activity of novel substituted 4, 5-dihydro-1H-1-pyrazolylmethanethiones [J].

Ali, Mohamed Ashraf ;

Yar, Mohammad Shahar .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2007, 22 (02) :183-189

[5] Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents [J].

Amir, Mohammad ;

Kumar, Harish ;

Khan, Suroor A. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (03) :918-922

[6] Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole [J].

Amnerkar, Nikhil D. ;

Bhusari, Kishore P. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (01) :149-159

[7] Synthesis, and analgesic and antiparkinsonian activities of thiopyrimidine, pyrane, pyrazoline, and thiazolopyrimidine derivatives from 2-chloro-6-ethoxy-4-acetylpyridine [J].

Amr, Abd El-Galil E. ;

Maigali, Soher S. ;

Abdulla, Mohamed M. .

MONATSHEFTE FUR CHEMIE, 2008, 139 (11) :1409-1415

[8] Synthesis and antiandrogenic activity of some new 3-substituted androstano[17,16-c]-5′-aryl-pyrazoline and their derivatives [J].

Amr, AEE ;

Abdel-Latif, NA ;

Abdalla, MM .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (02) :373-384

[9] Synthesis and characterization of new 3,5-dinaphthyl substituted 2-pyrazolines and study of their antimicrobial activity [J].

Azarifar, D ;

Shaebanzadeh, M .

MOLECULES, 2002, 7 (12) :885-895

[10] Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring: Synthesis and antibacterial activity [J].

Bai, Lin Shan ;

Wang, Yan ;

Liu, Xin Hua ;

Zhu, Hai Liang ;

Song, Bao An .

CHINESE CHEMICAL LETTERS, 2009, 20 (04) :427-430

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