Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide

被引：10
|
作者：
Rodina, T. A. [1 ,3 ]
Mel'nikov, E. S. [2 ,3 ]
Sokolov, A. V. [1 ,2 ]
Prokof'ev, A. B. [1 ,2 ,3 ]
Arkhipov, V. V. [1 ,2 ,3 ]
Aksenov, A. A. [2 ]
Pozdnyakov, D. L. [3 ]
机构：
[1] Minist Publ Hlth Russian Federat, Fed Sci Ctr Expert Evaluat Med Prod, Moscow 127051, Russia
[2] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia
[3] Moscow City Dept Hlth, IV Davydovsky Municipal Clin Hosp, Moscow 109240, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 06期
关键词：
carbamazepine; carbamazepine-10,11-epoxide; therapeutic drug monitoring; bioequivalence; interchangeability; HPLC-MS/MS; PERFORMANCE LIQUID-CHROMATOGRAPHY; ANTIEPILEPTIC DRUGS; METABOLITES; OXCARBAZEPINE; STRATEGIES; EPOXIDE; PLASMA;
D O I：
10.1007/s11094-016-1462-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 - 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 - 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.
引用
收藏
页码：419 / 423
页数：5
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