Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide

被引：10

作者：

Rodina, T. A. ^{[1
,3
]}

Mel'nikov, E. S. ^{[2
,3
]}

Sokolov, A. V. ^{[1
,2
]}

Prokof'ev, A. B. ^{[1
,2
,3
]}

Arkhipov, V. V. ^{[1
,2
,3
]}

Aksenov, A. A. ^{[2
]}

Pozdnyakov, D. L. ^{[3
]}

机构：

[1] Minist Publ Hlth Russian Federat, Fed Sci Ctr Expert Evaluat Med Prod, Moscow 127051, Russia

[2] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia

[3] Moscow City Dept Hlth, IV Davydovsky Municipal Clin Hosp, Moscow 109240, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 06期

关键词：

carbamazepine; carbamazepine-10,11-epoxide; therapeutic drug monitoring; bioequivalence; interchangeability; HPLC-MS/MS; PERFORMANCE LIQUID-CHROMATOGRAPHY; ANTIEPILEPTIC DRUGS; METABOLITES; OXCARBAZEPINE; STRATEGIES; EPOXIDE; PLASMA;

D O I：

10.1007/s11094-016-1462-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 - 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 - 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.

引用

页码：419 / 423

页数：5

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