Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide

被引：10
|
作者：
Rodina, T. A. [1 ,3 ]
Mel'nikov, E. S. [2 ,3 ]
Sokolov, A. V. [1 ,2 ]
Prokof'ev, A. B. [1 ,2 ,3 ]
Arkhipov, V. V. [1 ,2 ,3 ]
Aksenov, A. A. [2 ]
Pozdnyakov, D. L. [3 ]
机构：
[1] Minist Publ Hlth Russian Federat, Fed Sci Ctr Expert Evaluat Med Prod, Moscow 127051, Russia
[2] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia
[3] Moscow City Dept Hlth, IV Davydovsky Municipal Clin Hosp, Moscow 109240, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 06期
关键词：
carbamazepine; carbamazepine-10,11-epoxide; therapeutic drug monitoring; bioequivalence; interchangeability; HPLC-MS/MS; PERFORMANCE LIQUID-CHROMATOGRAPHY; ANTIEPILEPTIC DRUGS; METABOLITES; OXCARBAZEPINE; STRATEGIES; EPOXIDE; PLASMA;
D O I：
10.1007/s11094-016-1462-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 - 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 - 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.
引用
收藏
页码：419 / 423
页数：5
相关论文
共 50 条
  • [1] Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide
    T. A. Rodina
    E. S. Mel’nikov
    A. V. Sokolov
    A. B. Prokof’ev
    V. V. Arkhipov
    A. A. Aksenov
    D. L. Pozdnyakov
    Pharmaceutical Chemistry Journal, 2016, 50 : 419 - 423
  • [2] PHARMACOKINETICS OF CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE IN THE PIGLET
    KEARNS, GL
    HENDRY, IR
    CLINICAL RESEARCH, 1990, 38 (01): : A47 - A47
  • [3] In vitro embryotoxicity of carbamazepine and carbamazepine-10,11-epoxide
    Hansen, DK
    Dial, SL
    Terry, KK
    Grafton, TF
    TERATOLOGY, 1996, 54 (01) : 45 - 51
  • [4] CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE PHARMACOKINETICS IN AN OVERDOSE PATIENT
    PATSALOS, PN
    KRISHNA, S
    ELYAS, AA
    LASCELLES, PT
    HUMAN TOXICOLOGY, 1987, 6 (03): : 241 - 244
  • [5] CARBAMAZEPINE-10,11-EPOXIDE DETERMINED BY EMIT CARBAMAZEPINE REAGENT
    MONACO, F
    PIREDDA, S
    EPILEPSIA, 1980, 21 (05) : 475 - 477
  • [6] SIMULTANEOUS MEASUREMENT OF FELBAMATE AND CARBAMAZEPINE-10,11-EPOXIDE BY HPLC
    OU, CN
    ROGNERUD, CL
    CLINICAL CHEMISTRY, 1995, 41 (06) : S123 - S123
  • [7] Elevation of carbamazepine-10,11-epoxide by quetiapine
    Fitzgerald, BJ
    Okos, AJ
    PHARMACOTHERAPY, 2002, 22 (11): : 1500 - 1503
  • [8] METABOLISM OF CARBAMAZEPINE-10,11-EPOXIDE IN RATS
    PANTAROTTO, C
    BELVEDERE, G
    FRIGERIO, A
    FARMACO-EDIZIONE PRATICA, 1976, 31 (10): : 509 - 515
  • [9] SIMULTANEOUS ANALYSIS OF CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE BY GC-CI-MS, STABLE ISOTOPE METHODOLOGY
    TRAGER, WF
    LEVY, RH
    PATEL, IH
    NEAL, JN
    ANALYTICAL LETTERS, 1978, 11 (02) : 119 - 133
  • [10] CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE CONCENTRATIONS IN HUMAN-BRAIN
    MORSELLI, PL
    BARUZZI, A
    GERNA, M
    BOSSI, L
    PORTA, M
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 4 (05) : 535 - 540
12345