The association of arterial shear and flow-mediated dilation in diabetes

被引：18

作者：

Gibbs, Bethany Barone ^{[1
,2
]}

Dobrosielski, Devon A. ^{[3
]}

Lima, Michael ^{[3
]}

Bonekamp, Susanne ^{[4
]}

Stewart, Kerry J. ^{[3
]}

Clark, Jeanne M. ^{[2
]}

机构：

[1] Univ Pittsburgh, Dept Hlth & Phys Activ, Pittsburgh, PA 15260 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Johns Hopkins Sch Med, Div Cardiol, Dept Med, Baltimore, MD USA

[4] Johns Hopkins Sch Med, Div Radiol, Dept Med, Baltimore, MD USA

来源：

VASCULAR MEDICINE | 2011年 / 16卷 / 04期

关键词：

diabetes; endothelial function; shear rate; vascular responsiveness; ENDOTHELIAL FUNCTION; BRACHIAL-ARTERY; CARDIOVASCULAR EVENTS; ULTRASOUND ASSESSMENT; REACTIVE HYPEREMIA; STRESS; DILATATION; STIMULUS; ATHEROSCLEROSIS; DYSFUNCTION;

D O I：

10.1177/1358863X11411361

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

While adjusting flow-mediated dilation (FMD), a measure of vascular function, for shear rate may be important when evaluating endothelial-dependent vasodilation, the relationship of FMD with shear rate in study populations with cardiovascular risk factors is unclear. We aimed to investigate the association of four measures of shear rate (peak shear rate (SRpeak) and shear rate area under the curve through 30 seconds (SRAUC 0-30), 60 seconds (SRAUC 0-60), and time to peak dilation (SRAUC 0-ttp)) with FMD in 50 study subjects with type 2 diabetes and mild hypertension undergoing baseline FMD testing for an exercise intervention trial. Associations among measures of shear rate and FMD were evaluated using Pearson's correlations and R-2. The four measures of shear rate were highly correlated within subjects, with Pearson's correlations ranging from 0.783 (p < 0.001) to 0.972 (p < 0.001). FMD was associated with each measure of shear rate, having a correlation of 0.576 (p < 0.001) with SRAUC 0-30, 0.529 (p < 0.001) with SRAUC 0-60, and 0.512 (p < 0.001) with SRpeak. Nine of 50 subjects (18%) did not dilate following the shear stimulus. Among the 41 responders, FMD had a correlation of 0.517 (p < 0.001) with SRAUC 0-ttp and similar correlations to those found in the full sample for SRAUC 0-30, SRAUC 0-60, and SRpeak. In conclusion, shear rate appears to explain up to a third of between-person variability in FMD response and our results support the reporting of shear rate and FMD with and without adjustment for shear rate in similar clinical populations with CVD risk factors.

引用

页码：267 / 274

页数：8