Thyroid carcinoma in children and adolescents: Clinical characteristics and follow-up from two centers

被引:9
作者
Pan, Jing-Jing [1 ]
Zhao, Li [2 ]
Cheng, Rui [2 ]
Yang, Yang [2 ]
Hu, Yu-Hua [1 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Pediat & Neonatol, Nanjing 210008, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Childrens Hosp, Dept Neonatol, Guangzhou Rd 72, Nanjing 210008, Jiangsu, Peoples R China
关键词
Adolescents; characteristics; children; thyroid carcinoma; NODULES; CANCER; MANAGEMENT; RECURRENCE; SURGERY; ADULTS;
D O I
10.4103/jcrt.JCRT_167_16
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim of Study: The aim of this study was to analyze the clinical features and outcomes of thyroid carcinoma (TC) in children and adolescent population treated in our institution. Materials and Methods: We gathered 43 TC patients 18 years of age or under initial diagnosed between 2009 and 2010 from two hospitals. Patient's clinical characteristics, laboratory tests, and outcomes were collected and analyzed. Results: (1) The incidence of TC is higher in women (2.4 vs. 1.6). Papillary carcinoma accounted for the major type (67.4%). There was significant difference in tumor number, extra thyroidal invasion, and distant metastasis when compared with the children group (P < 0.05). There were higher proportions of patients with lymph node metastasis (LNM) and radioiodine therapy in adolescent patients. (2) Thyroid peroxidase antibody, thyroglobulin, thyroglobulin antibody, and urine iodine had higher levels as compared to the normal reference range. Moreover, FT3 and urine iodine showed statistical significances in adolescent group (P < 0.05). (3) Papillary carcinoma and medullary TC are more likely to have LNM extrathyroidal invasion. (4) No significant differences were seen in recurrence rate or survival rate. Pulmonary metastasis was the most common way of cancer metastasis. Conclusion: The initial workup is crucial in determining benign from malignant lesions. Surgery is the most effective therapy even if it is associated with more complications in children. There is an extremely good prognosis for pediatric TC even distant metastasis happens.
引用
收藏
页码:715 / 719
页数:5
相关论文
共 50 条
  • [31] Sociodemographic and clinical predictors of depression in children and adolescents at clinical high-risk for psychosis: Results of a two-year follow-up study
    Styss, Nick
    Michel, Chantal
    Osman, Naweed
    Walger, Petra
    Franscini, Mauricia
    Traber-Walker, Nina
    Schimmelmann, Benno G.
    Flueckiger, Rahel
    Romanos, Marcel
    Romer, Georg
    Schulte-Koerne, Gerd
    Greimel, Ellen
    Meisenzahl, Eva
    Reissner, Volker
    Schultze-Lutter, Frauke
    JOURNAL OF AFFECTIVE DISORDERS, 2025, 382 : 89 - 97
  • [32] Thyroid carcinoma in children and adolescents - Clinical aspects, diagnostic problems and therapeutic particulars
    Peix, JL
    Mabrut, JY
    Som, PV
    Berger, N
    ANNALES D ENDOCRINOLOGIE, 1998, 59 (02) : 113 - 119
  • [33] Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto's thyroiditis: a single-center experience
    Erbas, Irem Ceren
    Erbas, Ibrahim Mert
    Evliyaoglu, Olcay
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2021, 34 (08) : 987 - 994
  • [34] Prolactinomas in children under 14. Clinical presentation and long-term follow-up
    Liu, Yang
    Yao, Yong
    Xing, Bing
    Lian, Wei
    Deng, Kan
    Feng, Ming
    Wang, Renzhi
    CHILDS NERVOUS SYSTEM, 2015, 31 (06) : 909 - 916
  • [35] Risk factors for recurrence of differentiated thyroid carcinoma in children and adolescents: A retrospective cohort study
    Jia, Siyu
    Tang, Dengpeng
    Peng, Wen
    MEDICINE, 2023, 102 (50) : E36585
  • [36] Clinical follow-up in children with laryngomalacia
    Kockar, Tuba
    Utku, Hatice Sinav
    Gunduz, Mehmet
    Oktem, Sedat
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [37] Long-term follow-up and prognostic analysis of parotid tumors in children and adolescents
    Liu, Lei
    Xiang, Yuqing
    Shui, Chunyan
    Li, Chao
    Xiong, Lujing
    Hu, Jinchuan
    Ai, Hao
    Zhou, Yuqiu
    Jiang, Jian
    Cai, Yongcong
    LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, 2024, 9 (03):
  • [38] COVID-19 in Children: Clinical Characteristics and Follow-Up Study
    Pei-sen Ruan
    Hui-qing Xu
    Jun-hua Wu
    Qi-fa Song
    Hai-yan Qiu
    SN Comprehensive Clinical Medicine, 2020, 2 (10) : 1713 - 1716
  • [39] Histologic and Clinical Follow-Up of Thyroid Fine-Needle Aspirates in Pediatric Patients
    Partyka, Kristen L.
    Huang, Eric C.
    Cramer, Harvey M.
    Chen, Shaoxiong
    Wu, Howard H.
    CANCER CYTOPATHOLOGY, 2016, 124 (07) : 467 - 471
  • [40] Incidental thyroid papillary microcarcinoma: survival and follow-up
    Gorostis, Sophie
    Raguin, Thibaut
    Schneegans, Olivier
    Takeda, Catherine
    Debry, Christian
    Dupret-Bories, Agnes
    LARYNGOSCOPE, 2019, 129 (07) : 1722 - 1726