Needle-free vaccine delivery

被引：54

作者：

Kersten, Gideon ^{[1
]}

Hirschberg, Hoang ^{[1
]}

机构：

[1] Head Netherlands Vaccine Inst, Dept Res & Dev, NL-3720 AI Bilthoven, Netherlands

来源：

EXPERT OPINION ON DRUG DELIVERY | 2007年 / 4卷 / 05期

关键词：

adjuvants; dermal vaccination; jet injection; mucosal vaccination; needle free; vaccine;

D O I：

10.1517/17425247.4.5.459

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The need for minimally invasive delivery methods is urgent. As the number of registered vaccines increases, so does the number of injections. The use of sharps can be unsafe and needle immunisation is less suitable for mass immunisations during emergencies such as pandemics or bioterrorist attacks. The approach of combining vaccines has limitations due to high development costs, risk of pharmaceutical or immunological interference and economic risks. Advancements in the development of alternatives to injection with syringes and needles are discussed in this paper, and include: mucosal vaccination, injection without needles and vaccine delivery via the skin.

引用

页码：459 / 474

页数：16

共 140 条

[81] Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine [J].

Mikszta, John A. ;

Dekker, John P., III ;

Harvey, Noel G. ;

Dean, Cheryl H. ;

Brittingham, John M. ;

Huang, Joanne ;

Sullivan, Vincent J. ;

Dyas, Beverly ;

Roy, Chad J. ;

Ulrich, Robert G. .

INFECTION AND IMMUNITY, 2006, 74 (12) :6806-6810

[82] Elastic liposomes mediated transcutaneous immunization against Hepatitis B [J].

Mishra, Dinesh ;

Dubey, Vaibhav ;

Asthana, Abhay ;

Saraf, D. K. ;

Jain, N. K. .

VACCINE, 2006, 24 (22) :4847-4855

[83] Needle-free, non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatitis B virus [J].

Misra, A ;

Ganga, S ;

Upadhyay, P .

VACCINE, 1999, 18 (5-6) :517-523

[84] Immunization without needles [J].

Mitragotri, S .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (12) :905-916

[85] Innovation - Current status and future prospects of needle-free liquid jet injectors [J].

Mitragotri, Samir .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (07) :543-548

[86] Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen [J].

Mizuno, D ;

Ide-Kurihara, M ;

Ichinomiya, T ;

Kubo, F ;

Kido, H .

JOURNAL OF IMMUNOLOGY, 2006, 176 (02) :1122-1130

[87] Production of Escherichia coli heat labile toxin (LT) B subunit in soybean seed and analysis of its immunogenicity as an oral vaccine [J].

Moravec, Tomas ;

Schmidt, Monica A. ;

Herman, Eliot M. ;

Woodford-Thomas, Terry .

VACCINE, 2007, 25 (09) :1647-1657

[88] Intussusception among infants given an oral rotavirus vaccine. [J].

Murphy, TV ;

Gargiullo, PM ;

Massoudi, MS ;

Nelson, DB ;

Jumaan, AO ;

Okoro, CA ;

Zanardi, LR ;

Setia, S ;

Fair, E ;

LeBaron, CW ;

Schwartz, B ;

Wharton, M ;

Livingood, JR .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (08) :564-572

[89]

Mutsch M, 2004, NEW ENGL J MED, V350, P896, DOI 10.1056/NEJMoa030595

[90] Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system [J].

Nesburn, Anthony B. ;

Bettah, Ilham ;

Zhang, Xiuli ;

Zhu, Xiaoming ;

Chamberlain, Winston ;

Afifi, Rasha E. ;

Wechsler, Steven L. ;

BenMohamed, Lbachir .

OCULAR SURFACE, 2006, 4 (04) :178-187

← 4 5 6 7 8 9 10 11 12 13 →