The Next Frontier: Head and Neck Cancer Immunoprevention

被引：9
作者：
Gutkind, J. Silvio [1 ]
Bui, Jack D. [2 ]
机构：
[1] Univ Calif San Diego, Moores Canc Ctr, Dept Pharmacol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Moores Canc Ctr, Dept Pathol, La Jolla, CA 92093 USA
来源：
CANCER PREVENTION RESEARCH | 2017年 / 10卷 / 12期
关键词：
METFORMIN PREVENTS;
D O I：
10.1158/1940-6207.CAPR-17-0331
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Restoring T cell-mediated antitumor immunity by targeting immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) results in immunomodulation and durable remissions. However, the overall response rate to these immunotherapies in HNSCC is only approximately 20%. This raises the possibility that immunologic intervention earlier in the HNSCC continuum, such as in oral premalignant lesions (OPL) could elicit an increased therapeutic response. Newexperimental studies suggest that immune therapies can be used forHNSCCprevention rather than therapy. Given the current excitement for precision medicine, these findings support the future development of multimodality approaches for preventive immune oncology. (C) 2017 AACR.
引用
收藏
页码：681 / 683
页数：3
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