Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury

被引：3
作者：
Yu, Wenlei [1 ,2 ]
Lu, Linjie [1 ,2 ]
Ji, Xintong [1 ,2 ]
Qian, Qiwei [1 ,2 ]
Lin, Xiaohan [1 ]
Wang, Huanhuan [1 ,2 ]
机构：
[1] Hangzhou Normal Univ, Sch Basic Med Sci, Yuhangtang Rd 2318, Hangzhou 311121, Peoples R China
[2] Hangzhou Normal Univ, Lab Aging & Canc Biol Zhejiang Prov, Hangzhou, Peoples R China
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 84卷 / 01期
关键词：
Epigenetic regulation; nervous system damage (CNS); neuroinflammation; Porphyromonas gingivalis; OXIDATIVE STRESS; DISEASE; COMPLEMENT; ACTIVATION; PHOSPHORYLATION; INFLAMMATION; DYSFUNCTION; PROTEINS; ANTIBODY; MICE;
D O I：
10.3233/JAD-215143
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic periodontitis caused by Porphyromonas gingivalis (P. gingivalis) infection generally lasts for a lifetime. The long-term existence and development of P. gingivalis infection gradually aggravate the accumulation of inflammatory signals and toxic substances in the body. Recent evidence has revealed that P. gingivalis infection may be relevant to some central nervous system (CNS) diseases. The current work collects information and tries to explore the possible relationship between P. gingivalis infection and CNS diseases, including the interaction or pathways between peripheral infection and CNS injury, and the underlying neurotoxic mechanisms.
引用
收藏
页码：51 / 59
页数：9
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