The Role of Perilipins in the Development of Obesity and Obesity-Related Diseases

被引：2

作者：

Nicolaidou, Katerina ^{[1
]}

Isoldi, Kathy K. ^{[1
]}

Ramer, Nicholas J. ^{[1
]}

Sarcona, Alessandra ^{[1
]}

机构：

[1] Long Isl Univ, Brookville, NY USA

来源：

TOPICS IN CLINICAL NUTRITION | 2016年 / 31卷 / 03期

关键词：

genetics; obesity; perilipins; HORMONE-SENSITIVE LIPASE; LIPID DROPLET FORMATION; WEIGHT-LOSS; GENETIC-VARIATION; 11482G-GREATER-THAN-A POLYMORPHISM; ADIPOCYTE LIPOLYSIS; ADIPOSE-TISSUE; PLIN LOCUS; RISK; ACCUMULATION;

D O I：

10.1097/TIN.0000000000000078

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Understanding nonmodifiable factors promoting weight gain can help clinicians reduce their bias and improve patient care. This review outlines research linking perilipins with the regulation of body fat. Perilipins are proteins that coat lipid droplets. There are 5 known perilipins with varying functions, and perilipin 1 is the most widely researched of all. Rodent studies found a strong link between perilipin 1 and increased fat mass; however, studies with human subjects found inconsistencies, perhaps because of sex and genetic variations. Although some inconsistencies are evident, an association between perilipins and the development of obesity has been established.

引用

页码：248 / 256

页数：9

共 55 条

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