Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors

被引：47

作者：

Lozano, Manuel ^{[1
,2
]}

Murcia, Mario ^{[2
,3
,4
]}

Soler-Blasco, Raquel ^{[2
]}

Casas, Maribel ^{[3
,5
,6
]}

Zubero, Begotxu ^{[7
,8
]}

Riutort-Mayol, Gabriel ^{[9
]}

Gil, Fernando ^{[10
]}

Olmedo, Pablo ^{[10
]}

Grimalt, Joan O. ^{[11
]}

Amoros, Ruben ^{[2
]}

Lertxundi, Aitana ^{[3
,7
,8
]}

Vrijheid, Martine ^{[3
,5
,6
]}

Ballester, Ferran ^{[2
,3
,12
]}

Llop, Sabrina ^{[2
,3
]}

机构：

[1] Univ Valencia, Toxicol & Forens Med Dept, Prevent Med & Publ Hlth, Food Sci, Valencia, Spain

[2] Univ Valencia, Epidemiol & Environm Hlth Joint Res Unit, FISABIO, Univ Jaume I, Valencia, Spain

[3] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[4] Generalitat Valenciana, Serv Anal Sistemas Informat Sanitaria, Conselleria Sanitat, Valencia, Spain

[5] ISGIobal, Barcelona, Spain

[6] Univ Pompeu Fabra, Barcelona, Spain

[7] Univ Basque Country, Prevent Med & Publ Hlth Dept, UPV EHU, Leioa, Spain

[8] Hlth Res Inst, Biodonostia, San Sebastian, Spain

[9] Fdn Promot Hlth & Biomed Res Valencian Reg, FISABIO Publ Hlth, Valencian, Spain

[10] Univ Granada, Sch Med, Dept Legal Med & Toxicol, Granada, Spain

[11] Inst Environm Assessment & Water Res IDAEA CSIC, Barcelona, Spain

[12] Univ Valencia, Dept Nursing, Valencia, Spain

来源：

CHEMOSPHERE | 2022年 / 286卷

关键词：

Metals; Metalloids; Prenatal exposure; Environmental exposure; Diet; MATERNAL EXPOSURE; NEUROPSYCHOLOGICAL DEVELOPMENT; CHILD POPULATION; HEAVY-METALS; SELENIUM; LEAD; PREDICTORS; COHORT; BLOOD; DIET;

D O I：

10.1016/j.chemosphere.2021.131809

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus. Objectives: To describe the prenatal concentrations of metals and metalloids and to study the associated sociodemographic, environmental and dietary factors in pregnant Spanish women. Methods: Subjects were 1346 pregnant women of the INMA Project, for whom the following metals arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl) and zinc (Zn) were determined in urine, at both the first and the third trimesters of gestation. Sociodemographic, dietary and environmental information was collected through questionnaires during pregnancy. Multiple linear mixed models were built in order to study the association between each metal and metalloid concentrations and the sociodemographic, environmental and dietary factors. Results: The most detected compounds were As, Co, Mo, Sb, Se and Zn at both trimesters. Zn was the element found in the highest concentrations at both trimesters and Tl was detected in the lowest concentrations. We observed significant associations between As, Cd, Cu, Sb, Tl and Zn concentrations and working situation, social class and age. Seafood, meat, fruits, nuts, vegetables and alcohol intake affected the levels of all the metals but Cd and Cu. Proximity to industrial areas, fields and air pollution were related to all metals except Cd, Sb and Se. Conclusions: This is the first large prospective longitudinal study on the exposure to metals and metalloids during pregnancy and associated factors to include several cohorts in Spain. The present study shows that some modifiable lifestyles, food intakes and environmental factors could be associated with prenatal exposure to metal (loid)s, which may be considered in further studies to assess their relationship with neonatal health outcomes.

引用

页数：13

共 98 条

[1]

ALAEJOS MS, 1993, CLIN CHEM, V39, P2040

[2] Maternal copper status and neuropsychological development in infants and preschool children [J].