African American;
cardiovascular health;
genomics;
health disparities;
race and ethnicity;
SUBCLINICAL ATHEROSCLEROSIS;
PRECISION MEDICINE;
GENETIC-VARIANTS;
NATIONAL-SURVEY;
DIVERSITY;
D O I:
10.1097/JCN.0000000000000725
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background African Americans are more likely to die from cardiovascular disease (CVD) than all other populations in the United States. Although technological advances have supported rapid growth in applying genetics/genomics to address CVD, most research has been conducted among European Americans. The lack of African American representation in genomic samples has limited progress in equitably applying precision medicine tools, which will widen CVD disparities if not remedied. Purpose This report summarizes the genetic/genomic advances that inform precision health and the implications for cardiovascular disparities in African American adults. We provide nurse scientists recommendations for becoming leaders in developing precision health tools that promote population health equity. Conclusions Genomics will continue to drive advances in CVD prevention and management, and equitable progress is imperative. Nursing should leverage the public's trust and its widespread presence in clinical and community settings to prevent the worsening of CVD disparities among African Americans.
机构:
Georgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
NIH, Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Vargas, Jose D.
;
论文数: 引用数:
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机构:
Manichaikul, Ani
;
Wang, Xin-Qun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Biostat Sect, Dept Publ Hlth Sci, Charlottesville, VA USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Wang, Xin-Qun
;
Rich, Stephen S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Ctr Publ Hlth & Genom, Dept Publ Hlth Sci, Charlottesville, VA USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Rich, Stephen S.
;
Rotter, Jerome I.
论文数: 0引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Rotter, Jerome I.
;
Post, Wendy S.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Div Cardiol, Baltimore, MD USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Post, Wendy S.
;
Polak, Joseph F.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Dept Radiol, Boston, MA 02111 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Polak, Joseph F.
;
Budoff, Matthew J.
论文数: 0引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Budoff, Matthew J.
;
Bluemke, David A.
论文数: 0引用数: 0
h-index: 0
机构:
NIH, Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
机构:
Icahn Sch Med Mt Sinai, Dept Genet, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Dept Genom Sci, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USAUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
Sklar, Pamela
;
McCarthy, Mark I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Old Rd, Oxford OX3 7LJ, England
Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England
Churchill Hosp, Oxford NIHR Biomed Res Ctr, Old Rd, Oxford OX3 7LJ, EnglandUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
McCarthy, Mark I.
;
Brown, Matthew A.
论文数: 0引用数: 0
h-index: 0
机构:
Queensland Univ Technol, Inst Hlth & Biomed Innovat, Translat Res Inst, Princess Alexandra Hosp, Brisbane, Qld 4102, AustraliaUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
机构:
Georgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
NIH, Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Vargas, Jose D.
;
论文数: 引用数:
h-index:
机构:
Manichaikul, Ani
;
Wang, Xin-Qun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Biostat Sect, Dept Publ Hlth Sci, Charlottesville, VA USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Wang, Xin-Qun
;
Rich, Stephen S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Ctr Publ Hlth & Genom, Dept Publ Hlth Sci, Charlottesville, VA USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Rich, Stephen S.
;
Rotter, Jerome I.
论文数: 0引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Rotter, Jerome I.
;
Post, Wendy S.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Div Cardiol, Baltimore, MD USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Post, Wendy S.
;
Polak, Joseph F.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Dept Radiol, Boston, MA 02111 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Polak, Joseph F.
;
Budoff, Matthew J.
论文数: 0引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
Budoff, Matthew J.
;
Bluemke, David A.
论文数: 0引用数: 0
h-index: 0
机构:
NIH, Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USAGeorgetown Univ Hosp, MedStar Hlth Res Inst, Washington, DC 20007 USA
机构:
Icahn Sch Med Mt Sinai, Dept Genet, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Dept Genom Sci, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USAUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
Sklar, Pamela
;
McCarthy, Mark I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Old Rd, Oxford OX3 7LJ, England
Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England
Churchill Hosp, Oxford NIHR Biomed Res Ctr, Old Rd, Oxford OX3 7LJ, EnglandUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
McCarthy, Mark I.
;
Brown, Matthew A.
论文数: 0引用数: 0
h-index: 0
机构:
Queensland Univ Technol, Inst Hlth & Biomed Innovat, Translat Res Inst, Princess Alexandra Hosp, Brisbane, Qld 4102, AustraliaUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia