Equity in Genomics A Brief Report on Cardiovascular Health Disparities in African American Adults

被引:4
作者
Scott, Jewel [1 ]
Cousin, Lakeshia [2 ]
Woo, Jennifer [3 ]
Gonzalez-Guarda, Rosa [1 ]
Simmons, Leigh Ann [4 ]
机构
[1] Duke Univ, Sch Nursing, DUMC Box 3322,307 Trent Dr, Durham, NC 27710 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Hlth Outcomes & Behav, Tampa, FL USA
[3] Texas Womens Univ, Dallas, TX USA
[4] Univ Calif Davis, Dept Human Ecol, Davis, CA 95616 USA
关键词
African American; cardiovascular health; genomics; health disparities; race and ethnicity; SUBCLINICAL ATHEROSCLEROSIS; PRECISION MEDICINE; GENETIC-VARIANTS; NATIONAL-SURVEY; DIVERSITY;
D O I
10.1097/JCN.0000000000000725
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background African Americans are more likely to die from cardiovascular disease (CVD) than all other populations in the United States. Although technological advances have supported rapid growth in applying genetics/genomics to address CVD, most research has been conducted among European Americans. The lack of African American representation in genomic samples has limited progress in equitably applying precision medicine tools, which will widen CVD disparities if not remedied. Purpose This report summarizes the genetic/genomic advances that inform precision health and the implications for cardiovascular disparities in African American adults. We provide nurse scientists recommendations for becoming leaders in developing precision health tools that promote population health equity. Conclusions Genomics will continue to drive advances in CVD prevention and management, and equitable progress is imperative. Nursing should leverage the public's trust and its widespread presence in clinical and community settings to prevent the worsening of CVD disparities among African Americans.
引用
收藏
页码:58 / 63
页数:6
相关论文
共 35 条
  • [1] HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies
    Ackerman, Michael J.
    Priori, Silvia G.
    Willems, Stephan
    Berul, Charles
    Brugada, Ramon
    Calkins, Hugh
    Camm, A. John
    Ellinor, Patrick T.
    Gollob, Michael
    Hamilton, Robert
    Hershberger, Ray E.
    Judge, Daniel P.
    Le Marec, Herve
    McKenna, William J.
    Schulze-Bahr, Eric
    Semsarian, Chris
    Towbin, Jeffrey A.
    Watkins, Hugh
    Wilde, Arthur
    Wolpert, Christian
    Zipes, Douglas P.
    [J]. EUROPACE, 2011, 13 (08): : 1077 - 1109
  • [2] The "All of Us" Research Program
    Denny J.C.
    Rutter J.L.
    Goldstein D.B.
    Philippakis A.
    Smoller J.W.
    Jenkins G.
    Dishman E.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (07) : 668 - 676
  • [3] Branan M., NURSES AGAIN OUTPACE
  • [4] Cardiovascular Health in African Americans A Scientific Statement From the American Heart Association
    Carnethon, Mercedes R.
    Pu, Jia
    Howard, George
    Albert, Michelle A.
    Anderson, Cheryl A. M.
    Bertoni, Alain G.
    Mujahid, Mahasin S.
    Palaniappan, Latha
    Taylor, Herman A., Jr.
    Willis, Monte
    Yancy, Clyde W.
    [J]. CIRCULATION, 2017, 136 (21) : E393 - E423
  • [5] Distributive justice, diversity, and inclusion in precision medicine: what will success look like?
    Cohn, Elizabeth G.
    Henderson, Gail E.
    Appelbaum, Paul S.
    [J]. GENETICS IN MEDICINE, 2017, 19 (02) : 157 - 159
  • [6] Coleman Bernice, 2018, J Natl Black Nurses Assoc, V29, P9
  • [7] Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program
    Ehret, Georg B.
    Morrison, Alanna C.
    O'Connor, Ashley A.
    Grove, Megan L.
    Baird, Lisa
    Schwander, Karen
    Weder, Alan
    Cooper, Richard S.
    Rao, D. C.
    Hunt, Steven C.
    Boerwinkle, Eric
    Chakravarti, Aravinda
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2008, 16 (12) : 1507 - 1511
  • [8] Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans
    Gong, Yan
    Wang, Zhiying
    Beitelshees, Amber L.
    McDonough, Caitrin W.
    Langaee, Taimour Y.
    Hall, Karen
    Schmidt, Siegfried O. F.
    Curry, Robert W., Jr.
    Gums, John G.
    Bailey, Kent R.
    Boerwinkle, Eric
    Chapman, Arlene B.
    Turner, Stephen T.
    Cooper-DeHoff, Rhonda M.
    Johnson, Julie A.
    [J]. HYPERTENSION, 2016, 67 (03) : 556 - 563
  • [9] Interactive Influences of Ethnicity, Endothelin-1 Gene, and Everyday Discrimination Upon Nocturnal Ambulatory Blood Pressure
    Gregoski, Mathew J.
    Buxbaum, Sarah G.
    Kapuku, Gaston
    Dong, Yanbin
    Zhu, Haidong
    Davis, Mary
    Gonto, Kelsey
    Treiber, Frank A.
    [J]. ANNALS OF BEHAVIORAL MEDICINE, 2013, 45 (03) : 377 - 386
  • [10] A common variant on chromosome 9p21 affects the risk of myocardial infarction
    Helgadottir, Anna
    Thorleifsson, Gudmar
    Manolescu, Andrei
    Gretarsdottir, Solveig
    Blondal, Thorarinn
    Jonasdottir, Aslaug
    Jonasdottir, Adalbjorg
    Sigurdsson, Asgeir
    Baker, Adam
    Palsson, Arnar
    Masson, Gisli
    Gudbjartsson, Daniel F.
    Magnusson, Kristinn P.
    Andersen, Karl
    Levey, Allan I.
    Backman, Valgerdur M.
    Matthiasdottir, Sigurborg
    Jonsdottir, Thorbjorg
    Palsson, Stefan
    Einarsdottir, Helga
    Gunnarsdottir, Steinunn
    Gylfason, Arnaldur
    Vaccarino, Viola
    Hooper, W. Craig
    Reilly, Muredach P.
    Granger, Christopher B.
    Austin, Harland
    Rader, Daniel J.
    Shah, Svati H.
    Quyyumi, Arshed A.
    Gulcher, Jeffrey R.
    Thorgeirsson, Gudmundur
    Thorsteinsdottir, Unnur
    Kong, Augustine
    Stefansson, Kari
    [J]. SCIENCE, 2007, 316 (5830) : 1491 - 1493