Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia

被引：1
|
作者：
Medeiros, Fernanda Silva [1 ]
de Mendonca, Taciana Furtado [2 ]
de Miranda Lopes, Katiuscia Araujo [1 ]
da Camara Franca, Lais Medeiros [1 ]
da Silva, Andreia Soares [1 ]
Silva Vasconcelos, Luydson Richardson [3 ]
Valgueiro Costa de Oliveira, Maria do Carmo [4 ]
Mendonca dos Anjos, Ana Claudia [4 ]
Domingues Hatzlhofer, Betania Lucena [5 ]
Cavalcanti Bezerra, Marcos Andre [5 ]
Araujo, Aderson da Silva [4 ]
Moura, Patricia [1 ]
de Mendonca Cavalcanti, Maria do Socorro [1 ]
机构：
[1] Univ Pernambuco, Fac Ciencias Med, Inst Ciencias Biol, Recife, PE, Brazil
[2] Univ Fed Rural Pernambuco, Programa Posgrad Biotecnol RENORBIO, Recife, PE, Brazil
[3] Fiocruz MS, Ctr Pesquisa Aggeu Magalhaes, Recife, PE, Brazil
[4] Hosp Hematol & Hemoterapia Pernambuco HEMOPE, Recife, PE, Brazil
[5] Univ Fed Pernambuco, Recife, PE, Brazil
来源：
GENETICS AND MOLECULAR BIOLOGY | 2017年 / 40卷 / 03期
关键词：
MBL2; polymorphism; sickle cell anemia; vaso-occlusive events; DISEASE; ERYTHROCYTES; COMPLEMENT; C1Q; CRISIS;
D O I：
10.1590/1678-4685-GMB-2016-0161
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sickle cell anemia (SCA) presents heterogenous clinical manifestations that cannot be explained solely by alterations to hemoglobin (Hb); other components such as endothelial adhesion, thrombosis and inflammation may be involved. The mannose-binding lectin (MBL) has an important role in innate immunity and inflammatory diseases. In this report, we describe an association betweenMBL2 polymorphism related to low production of serum MBL and the frequency of vasoocclusive events (FVOE) in children <= 5 years old with SCA (p = 0.0229; OR 5.55; CI 1.11-27.66). Further studies are needed to explore the role of low MBL2 in the pathophysiology of vasoocclusive events in SCA.
引用
收藏
页码：600 / 603
页数：4
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