The Prognostic Significance of IGF-1R and the Predictive Risk Value of Circulating IGF-1 in Tunisian Patients with Laryngeal Carcinoma

被引：6
作者：
Ben Elhadj, Mariem [1 ,2 ]
Goucha, Aida [1 ]
Fourati, Asma [1 ,2 ]
Adouni, Olfa [1 ]
Dhambri, Sawsen [3 ]
Hsairi, Mohamed [4 ]
El May, Michele-Veronique [2 ]
Baizig, Nehla Mokni [1 ,2 ]
机构：
[1] Salah Azaiez Canc Inst, Dept Immunohistocytol, Pl Bab Saadoun, Tunis 1006, Tunisia
[2] Univ Tunis El Manar, Res Unit 17 ES 13, Fac Med, Tunis, Tunisia
[3] Salah Azaiez Canc Inst, Dept ORL, Tunis, Tunisia
[4] Salah Azaiez Canc Inst, Dept Epidemiol, Tunis, Tunisia
来源：
CANCER INVESTIGATION | 2020年 / 38卷 / 05期
关键词：
IGF-1; IGF-1R; prognostic significance; predictive risk value; laryngeal carcinoma; Tunisia; GROWTH-FACTOR-I; FACTOR RECEPTOR; CLINICAL-SIGNIFICANCE; MONOCLONAL-ANTIBODY; BINDING-PROTEINS; SERUM-LEVELS; INSULIN; CANCER; EXPRESSION; HEAD;
D O I：
10.1080/07357907.2020.1758711
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim was to evaluate the clinical impact of IGF-1/IGF-1R in Tunisian laryngeal carcinoma. A high IGF-1R immunohistochemical expression was found in our series (81.43%). A tendency toward an association between IGF-1R expression and lymph node metastasis was found (p = 0.068). Patients with positive IGF-1R expression showed a short disease free survival (p = 0.053) and a high recurrence rate. Furthermore, circulating IGF-1 levels sera, detected by ELISA, were higher among patients compared to controls (p < 0.001). IGF-1R might have a prognostic significance and could be a factor of tumor recurrence. However, high levels of IGF-1 increase the risk of developing of LSCC disease.
引用
收藏
页码：289 / 299
页数：11
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