Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study

被引:82
作者
Bertram, Lisa A. Cadmus [1 ]
Stefanick, Marcia L. [2 ]
Saquib, Nazmus [1 ]
Natarajan, Loki [1 ]
Patterson, Ruth E. [1 ]
Bardwell, Wayne [1 ]
Flatt, Shirley W. [1 ]
Newman, Vicky A. [1 ]
Rock, Cheryl L. [1 ]
Thomson, Cynthia A. [3 ]
Pierce, John P. [1 ]
机构
[1] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 94305 USA
[2] Stanford Univ, Stanford Prevent Res Ctr, Stanford, CA 94305 USA
[3] Univ Arizona, Arizona Canc Ctr, Dept Nutr Sci, Tucson, AZ 85721 USA
关键词
Exercise; Recurrence; Survival; Behavior; Lifestyle; RISK; HEALTH; WOMEN; TRIAL; FRUIT;
D O I
10.1007/s10552-010-9714-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective Research suggests that physical activity is associated with improved breast cancer survival, yet no studies have examined the association between post-diagnosis changes in physical activity and breast cancer outcomes. The aim of this study was to determine whether baseline activity and 1-year change in activity are associated with breast cancer events or mortality. Methods A total of 2,361 post-treatment breast cancer survivors (Stage I-III) enrolled in a randomized controlled trial of dietary change completed physical activity measures at baseline and one year. Physical activity variables (total, moderate-vigorous, and adherence to guidelines) were calculated for each time point. Median follow-up was 7.1 years. Outcomes were invasive breast cancer events and all-cause mortality. Results Those who were most active at baseline had a 53% lower mortality risk compared to the least active women (HR = 0.47; 95% CI: 0.26, 0.84; p = .01). Adherence to activity guidelines was associated with a 35% lower mortality risk (HR = 0.65, 95% CI: 0.47, 0.91; p < 01). Neither baseline nor 1-year change in activity was associated with additional breast cancer events. Conclusions Higher baseline (post-treatment) physical activity was associated with improved survival. However, change in activity over the following year was not associated with outcomes. These data suggest that long-term physical activity levels are important for breast cancer prognosis.
引用
收藏
页码:427 / 435
页数:9
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