Butyrolactones from the Endophytic Fungus Aspergillus versicolor and their Anti-Tobacco Mosaic Virus Activity

被引：24

作者：

Zhou, Min ^{[1
,2
]}

Lou, Jie ^{[1
,2
]}

Li, Yin-Ke ^{[3
]}

Wang, Yue-De ^{[1
,2
]}

Zhou, Kun ^{[1
,2
]}

Ji, Bing-Kun ^{[1
,2
]}

Dong, Wei ^{[1
,2
]}

Gao, Xue-Mei ^{[1
,2
]}

Du, Gang ^{[1
,2
]}

Hu, Qiu-Fen ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China

[2] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Peoples R China

[3] Yuxi Normal Univ, Coll Resource & Environm, Yuxi 653100, Peoples R China

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2015年 / 26卷 / 03期

关键词：

butyrolactones; Aspergillus versicolor; anti-tobacco mosaic virus; TERREUS; DERIVATIVES; STRAIN;

D O I：

10.5935/0103-5053.20150008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New butyrolactones aspernolides C and D, along with two known butyrolactones (A and B) were isolated from the culture of the endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D nuclear magnetic ressonance techniques, and electronic circular dichroism. The butyrolactones aspernolides C and D were tested for their anti-tobacco mosaic virus activity. The results showed that butyrolactones aspernolides C and D exhibited moderate anti-tobacco mosaic virus activity with IC50 values of 64.2 and 88.6 mu M, respectively.

引用

页码：545 / 549

页数：5

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