Migraine Prophylaxis With Topiramate and Bone Health in Women

被引：10

作者：

Ali, Imran I. ^{[1
]}

Herial, Nabeel A. ^{[1
]}

Orris, Megan ^{[2
]}

Horrigan, Terrance ^{[3
]}

Tietjen, Gretchen E. ^{[1
]}

机构：

[1] Univ Toledo, Dept Neurol, Coll Med, Toledo, OH 43614 USA

[2] Univ Toledo, Dept Pediat, Coll Med, Toledo, OH 43614 USA

[3] Univ Toledo, Dept Obstet & Gynecol, Coll Med, Toledo, OH 43614 USA

来源：

HEADACHE | 2011年 / 51卷 / 04期

关键词：

antiepileptic drugs; topiramate; migraine; bone density; energy X-ray absorptiometry scan; vitamin D; ANTIEPILEPTIC DRUGS; EPILEPSY;

D O I：

10.1111/j.1526-4610.2011.01863.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antiepileptic drugs (AEDs) are commonly used for prevention of migraine headaches. Bone loss is a known complication, particularly associated with use of older AEDs. Topiramate is a newer AED, widely used for migraine prevention, but no evidence is currently available on its effect on bone metabolism. In a clinic-based pilot study, we evaluated bone health by examining biochemical and radiological markers of bone metabolism, in women with migraine. Osteopenia was noted in 53% of the patients and was associated with the duration of exposure to topiramate (P=.04).

引用

页码：613 / 616

页数：4

共 14 条

[1] Antiepileptic drugs and reduced bone mineral density [J].

Ali, II ;

Schuh, L ;

Barkley, GL ;

Gates, JR .

EPILEPSY & BEHAVIOR, 2004, 5 (03) :296-300

[2] Possible methods for the prevention of bone loss in persons with epilepsy [J].

Elliott, John O. .

EXPERT REVIEW OF NEUROTHERAPEUTICS, 2009, 9 (06) :797-812

[3] Antiepileptic drug use increases rates of bone loss in older women - A prospective study [J].

Ensrud, KE ;

Walczak, TS ;

Blackwell, T ;

Ensrud, ER ;

Bowman, PJ ;

Stone, KL .

NEUROLOGY, 2004, 62 (11) :2051-2057

[4]

*JANSS KOR LTD, CROSS SECT COMP MULT

[5]

Landmark CJ, 2008, CNS DRUGS, V22, P27

[6] Migraine prevalence, disease burden, and the need for preventive therapy [J].

Lipton, R. B. ;

Bigal, M. E. ;

Diamond, M. ;

Freitag, F. ;

Reed, M. L. ;

Stewart, W. F. .

NEUROLOGY, 2007, 68 (05) :343-349

[7] Effect of topiramate on acid-base balance: extent, mechanism and effects [J].

Mirza, Nasir ;

Marson, Anthony G. ;

Pirmohamed, Munir .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 68 (05) :655-661

[8] Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy [J].

Pack, A. M. ;

Morrell, M. J. ;

Randall, A. ;

McMahon, D. J. ;

Shane, E. .

NEUROLOGY, 2008, 70 (18) :1586-1593

[9] Adverse effects of antiepileptic drugs on bone structure - Epidemiology, mechanisms and therapeutic implications [J].

Pack, AM ;

Morrell, MJ .

CNS DRUGS, 2001, 15 (08) :633-642

[10] Epilepsy and bone health in adults [J].

Pack, AM ;

Morrell, MJ .

EPILEPSY & BEHAVIOR, 2004, 5 :S24-S29

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