In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules

被引：184

作者：

De Koker, Stefaan ^{[2
,3
]}

De Geest, Bruno G. ^{[4
]}

Cuvelier, Claude ^{[5
]}

Ferdinande, Liesbeth ^{[5
]}

Deckers, Wies ^{[2
,3
]}

Hennink, Wim E. ^{[4
]}

De Smedt, Stefaan ^{[1
]}

Mertens, Nico ^{[2
,3
]}

机构：

[1] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium

[2] Dept Mol Biomed Res, B-9052 Ghent, Belgium

[3] Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium

[4] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

[5] Univ Ghent, Dept Pathol, B-9000 Ghent, Belgium

来源：

ADVANCED FUNCTIONAL MATERIALS | 2007年 / 17卷 / 18期

关键词：

D O I：

10.1002/adfm.200700416

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyelectrolyte microcapsules are made by layer-by-layer (LbL) coating of a sacrificial template, followed by decomposition of the template, to produce hollow microcapsules. In this paper, we report on the in vivo cellular uptake, degradation and biocompatibility of polyelectrolyte microcapsules produced from alternating dextran sulphate and poly-L-arginine layers on a template of calcium carbonate microparticles. We show that a moderate tissue reaction is observed after subcutaneous injection of polyelectrolyte microcapsules in mice. Within sixteen days after subcutaneous injection, most of the microcapsules are internalized by the cells and start to get degraded. The number of polyelectrolyte layers determines the stability of the microcapsules after cellular uptake.

引用

页码：3754 / 3763

页数：10

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