Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses

被引:15
作者
Baber, SR [1 ]
Hyman, AL [1 ]
Kadowitz, PJ [1 ]
机构
[1] Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2003年 / 285卷 / 06期
关键词
cyclooxygenase; prostanoid synthesis; pulmonary and systemic pressor responses; vasoconstrictor peptide; NS-398; SC-560; SC-236;
D O I
10.1152/ajpheart.00294.2003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The role of cyclooxygenase (COX)-1 and -2 in prostanoid formation and modulation of pressor responses to ANG II was investigated in the pulmonary and systemic vascular beds in the rat. In the present study, selective COX-1 and -2 inhibitors attenuated increases in pulmonary arterial pressure and decreases in systemic arterial pressure in response to arachidonic acid but did not alter responses to PGE(1) or U-46619. The selective COX-1 and -2 inhibitors did not modify systemic pressor responses to injections or infusions of ANG II or pulmonary pressor responses to injections of the peptide. COX-2 inhibitors did not alter, whereas a COX-1 inhibitor depressed, arachidonic acid-induced platelet aggregation. These data provide evidence in support of the hypothesis that prostanoid synthesis occurs by way of the COX-1 and -2 pathways in the pulmonary and systemic vascular beds but that pressor responses to ANG II are not mediated or modulated by these pathways in the rat.
引用
收藏
页码:H2399 / H2410
页数:12
相关论文
共 37 条
[1]  
ALMATHE AAH, 1978, J PHARMACOL EXP THER, V207, P388
[2]   Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells [J].
Asano, K ;
Lilly, CM ;
Drazen, JM .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1996, 271 (01) :L126-L131
[3]  
BARNETT J, 1994, BIOCHIM BIOPHYS ACTA, V1209, P230
[4]   High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors [J].
Bauer, AK ;
Dwyer-Nield, LD ;
Malkinson, AM .
CARCINOGENESIS, 2000, 21 (04) :543-550
[5]   Role of AT1 receptors and autonomic nervous system in mediating acute presser responses to ANG II in anesthetized mice [J].
Bivalacqua, TJ ;
Dalal, A ;
Champion, HC ;
Kadowitz, PJ .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 277 (05) :E838-E847
[6]   Cyclooxygenase-1 and-2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning [J].
Camitta, MGW ;
Gabel, SA ;
Chulada, P ;
Bradbury, JA ;
Langenbach, R ;
Zeldin, DC ;
Murphy, E .
CIRCULATION, 2001, 104 (20) :2453-2458
[7]  
Catella-Lawson F, 1999, J PHARMACOL EXP THER, V289, P735
[8]   Responses to angiotensin peptides are mediated by AT1 receptors in the rat [J].
Champion, HC ;
Czapla, MA ;
Kadowitz, PJ .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1998, 274 (01) :E115-E123
[9]   INFLUENCE OF INHIBITORS OF PROSTAGLANDIN SYNTHESIS ON RENAL VASCULAR-RESISTANCE AND ON RENAL VASCULAR-RESPONSES TO VASOPRESSOR AND VASODILATOR AGENTS IN CAT [J].
CHAPNICK, BM ;
PAUSTIAN, PW ;
FEIGEN, LP ;
JOINER, PD ;
HYMAN, AL ;
KADOWITZ, PJ .
CIRCULATION RESEARCH, 1977, 40 (04) :348-354
[10]  
Cullen L, 1998, J PHARMACOL EXP THER, V287, P578