Influence of sustained hypoxia on the sensation of dyspnea

被引：13

作者：

Chonan, T ^{[1
]}

Okabe, S ^{[1
]}

Hida, W ^{[1
]}

Satoh, M ^{[1
]}

Kikuchi, Y ^{[1
]}

Takishima, T ^{[1
]}

Shirato, K ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Internal Med 1, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

JAPANESE JOURNAL OF PHYSIOLOGY | 1998年 / 48卷 / 04期

关键词：

hypoxic ventilatory depression; respiratory sensation; exercise;

D O I：

10.2170/jjphysiol.48.291

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We assessed the effect of sustained isocapnic hypoxia (PCO2 = 40 Torr, Sa(O2) = 80%) on the sensation of dyspnea in 16 normal healthy males. Subjects rated the sensation of dyspnea (psi) on 15 cm visual analog scales during 20 min of sustained hypoxia. Following this hypoxic period, 8 subjects undertook mild exercise (10-50 W on a bicycle ergometer for 3 min) under the continuation of hypoxia. During sustained hypoxia, psi increased initially with ventilation from 0.6 +/- 0.2 (n = 16, mean +/- SE) to 2.9 +/- 0.6 at peak ventilation, but it decreased with ventilatory depression to 1.6 +/- 0.4. Dyspnea intensity during hypoxic exercise was significantly smaller than that at peak ventilation in the resting hypoxic period (2.3 +/- 0.7 vs. 3.9 +/- 1.0), although the ventilation was greater during exercise (24.0 +/- 3.0 vs. 19.7 +/- 1.4 l/min). These results indicate that sustained hypoxia has a biphasic, i.e., initial stimulatory and delayed depressant, effect on dyspnea and on ventilation. It is suggested that the dyspnea sensing mechanism is suppressed during mild exercise under sustained hypoxia.

引用

页码：291 / 295

页数：5