PROGNOSTIC SIGNIFICANCE OF NUCLEAR pSTAT3 IN ORAL CANCER

被引：85

作者：

Macha, Muzafar A. ^{[1
]}

Matta, Ajay ^{[1
]}

Kaur, Jatinder ^{[1
]}

Chauhan, S. S. ^{[1
]}

Thakar, Alok ^{[2
]}

Shukla, Nootan K. ^{[3
]}

Gupta, Siddhartha Datta ^{[4
]}

Ralhan, Ranju ^{[5
,6
,7
,8
]}

机构：

[1] All India Inst Med Sci, Dept Biochem, Dr BR Ambedkar Inst Rotary Canc Hosp, New Delhi 110029, India

[2] All India Inst Med Sci, Dept Otorhinolaryngol, Dr BR Ambedkar Inst Rotary Canc Hosp, New Delhi, India

[3] All India Inst Med Sci, Dept Surg, Dr BR Ambedkar Inst Rotary Canc Hosp, New Delhi 110029, India

[4] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India

[5] Mt Sinai Hosp, Joseph & Mildred Sonshine Family Ctr Head & Neck, Toronto, ON M5G 1X5, Canada

[6] Mt Sinai Hosp, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 1X5, Canada

[7] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[8] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 04期

关键词：

pSTAT3; STAT3; leukoplakia; dysplasia; OSCC; SQUAMOUS-CELL CARCINOMA; NF-KAPPA-B; CONSTITUTIVE ACTIVATION; SIGNAL TRANSDUCERS; SMOKELESS TOBACCO; VEGF EXPRESSION; BREAST-CANCER; LUNG-CANCER; IN-VIVO; STAT3;

D O I：

10.1002/hed.21468

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Aberrant nuclear accumulation of proteins influences tumor development and may predict biologic aggressiveness and disease prognosis. This study determined the prognostic significance of pSTAT3 (phosphorylayed signal transducer and activator of transcription 3) in oral squamous cell carcinomas (OSCCs). Methods and Results. Using immunohistochemistry, a significant increase in nuclear accumulation of pSTAT3 was observed in 49 of 90 leukoplakias (54.4%) and 63/94 OSCCs (67%) (p(trend) < .001). Increased pSTAT3 was associated with tumor stage (p = .01), nodal metastasis (p = .0018), and tobacco consumption (p = .004). Kaplan-Meier analysis demonstrated that OSCC with increased nuclear pSTAT3 showed significantly reduced disease-free survival (13 months), compared with the patients with no nuclear pSTAT3 expression (64 months, p = .019). Cox regression analysis revealed nuclear pSTAT3 as the most significant predictor of poor prognosis (p = .024, hazard ratio [HR] = 2.7). Conclusions. Increased nuclear accumulation of pSTAT3 occurs in early premalignant stages and is a marker for poor prognosis of OSCC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 482-489, 2011

引用

页码：482 / 489

页数：8

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