A Critical Review about Human Exposure to Polychlorinated Dibenzo-p-Dioxins (PCDDs), Polychlorinated Dibenzofurans (PCDFs) and Polychlorinated Biphenyls (PCBs) through Foods

被引：86
作者：
Fernandez-Gonzalez, R. [1 ]
Yebra-Pimentel, I. [1 ]
Martinez-Carballo, E. [1 ]
Simal-Gandara, J. [1 ]
机构：
[1] Univ Vigo, Fac Food Sci & Technol, Dept Analyt & Food Chem, Nutr & Bromatol Grp, E-32004 Orense, Spain
来源：
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2015年 / 55卷 / 11期
关键词：
Polychlorinated dibenzo-p-dioxins (PCDDs); polychlorinated dibenzofurans (PCDFs); polychlororinated biphenyls (PCBs); human exposure; occurrence in foods; bioaccumulation; methods of removal; health effects; IN-VITRO DIGESTION; POLYCYCLIC AROMATIC-HYDROCARBONS; TOXIC EQUIVALENCY FACTORS; THYROID-HORMONE STATUS; METHYLSULFONYL METABOLITES; ENVIRONMENTAL EXPOSURE; DIETARY EXPOSURE; FISH-OIL; AEROBIC BIODEGRADATION; CONGENER DISTRIBUTIONS;
D O I：
10.1080/10408398.2012.710279
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Dioxins include polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and part of polychlorinated biphenyls (PCBs). Only the compounds that are chlorinated at the 2,3,7, and 8 positions have characteristic dioxin toxicity. PCDDs, PCDFs and PCBs accumulate in the food chain due to their high lipophilicity, high stability, and low vapor pressure. They are not metabolized easily; however their hydroxylated metabolites are detected in feces. They cause a wide range of endocrine disrupting effects in experimental animals, wildlife, and humans. Endocrine related effects of PCDDs, PCDFs and PCBs on thyroid hormones, neurodevelopment and reproductive development were referenced. In addition, some studies of contamination of foods, bioaccumulation, dietary exposure assessment, as well as challenges of scientific research in these compounds were reviewed.
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页码：1590 / 1617
页数：28
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