Disseminated Mycobacterium avium Infection Presenting with Bladder Lesions in a Patient with Interferon-γ-neutralizing Autoantibodies

被引：5

作者：

Miyashita, Koichi ^{[1
,2
]}

Matsuura, Shun ^{[1
]}

Tajima, Kenichi ^{[3
]}

Tajima, Shogo ^{[4
]}

Aoki, Ami ^{[5
]}

Sakagami, Takuro ^{[5
]}

Koshimizu, Naoki ^{[1
]}

Toyoshima, Mikio ^{[6
]}

Suda, Takafumi ^{[7
]}

机构：

[1] Fujieda City Gen Hosp, Dept Resp Med, Fujieda, Shizuoka, Japan

[2] Seirei Hamamatsu Gen Hosp, Dept Pulm Med, Hamamatsu, Shizuoka, Japan

[3] Fujieda City Gen Hosp, Dept Urol, Fujieda, Shizuoka, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Pathol, Tokyo, Japan

[5] Niigata Univ, Grad Sch Med & Dent Sci, Dept Resp Med & Infect Dis, Niigata, Japan

[6] Hamamatsu Rosai Hosp, Dept Resp Med, Hamamatsu, Shizuoka, Japan

[7] Hamamatsu Univ, Sch Med, Dept Internal Med 2, Hamamatsu, Shizuoka, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 20期

关键词：

disseminated nontuberculous mycobacterial infections; interferon-gamma neutralizing autoantibodies; bladder lesion; sterile pyuria; COMPLEX INFECTION; TUBERCULOSIS; TAIWAN; ASSAY;

D O I：

10.2169/internalmedicine.0965-18

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 63-year-old woman presented with a fever, eruption, and sterile pyuria. A cystoscopic examination revealed submucosal nodular lesions in the trigone of the bladder, and a biopsy specimen showed epithelioid cell granulomas in the lamina propria of the bladder. Mycobacterium avium grew in the urine culture. Other organ involvement, such as the lungs, spleen, bones, muscles, and pelvic lymph nodes, was observed on radiological examinations, and M. avium was isolated from some organ lesions. Interferon-gamma-neutralizing autoantibodies were detected in the patient's serum. Therefore, the patient was diagnosed with disseminated M. avium infection, which was resolved with antimycobacterial treatment.

引用

页码：3041 / 3045

页数：5

共 19 条

[1]

Ang D., 2006, SMJ Singapore Medical Journal, V47, P747

[2] Clinical Significance of Interferon-γ Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease [J].

Aoki, Ami ;

Sakagami, Takuro ;

Yoshizawa, Kazutaka ;

Shima, Kenjiro ;

Toyama, Mio ;

Tanabe, Yoshinari ;

Moro, Hiroshi ;

Aoki, Nobumasa ;

Watanabe, Satoshi ;

Koya, Toshiyuki ;

Hasegawa, Takashi ;

Morimoto, Kozo ;

Kurashima, Atsuyuki ;

Hoshino, Yoshihiko ;

Trapnell, Bruce C. ;

Kikuchi, Toshiaki .

CLINICAL INFECTIOUS DISEASES, 2018, 66 (08) :1239-1245

[3] Adult-Onset Immunodeficiency in Thailand and Taiwan [J].

Browne, Sarah K. ;

Burbelo, Peter D. ;

Chetchotisakd, Ploenchan ;

Suputtamongkol, Yupin ;

Kiertiburanakul, Sasisopin ;

Shaw, Pamela A. ;

Kirk, Jennifer L. ;

Jutivorakool, Kamonwan ;

Zaman, Rifat ;

Ding, Li ;

Hsu, Amy P. ;

Patel, Smita Y. ;

Olivier, Kenneth N. ;

Lulitanond, Viraphong ;

Mootsikapun, Piroon ;

Anunnatsiri, Siriluck ;

Angkasekwinai, Nasikarn ;

Sathapatayavongs, Boonmee ;

Hsueh, Po-Ren ;

Shieh, Chi-Chang ;

Brown, Margaret R. ;

Thongnoppakhun, Wanna ;

Claypool, Reginald ;

Sampaio, Elizabeth P. ;

Thepthai, Charin ;

Waywa, Duangdao ;

Dacombe, Camilla ;

Reizes, Yona ;

Zelazny, Adrian M. ;

Saleeb, Paul ;

Rosen, Lindsey B. ;

Mo, Allen ;

Iadarola, Michael ;

Holland, Steven M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (08) :725-734

[4]

Dasgupta Alakananda, 2009, J Lab Physicians, V1, P56, DOI 10.4103/0974-2727.59700

[5]

Döffinger R, 2004, CLIN INFECT DIS, V38, P602

[6] Naturally occurring anti-IFN-γ autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans [J].

Höflich, C ;

Sabat, R ;

Rosseau, S ;

Temmesfeld, B ;

Slevogt, H ;

Döcke, WD ;

Grütz, G ;

Meisel, C ;

Halle, E ;

Göbel, UB ;

Volk, HD ;

Suttorp, N .

BLOOD, 2004, 103 (02) :673-675

[7] Genitourinary infections caused by nontuberculous mycobacteria at a university hospital in Taiwan, 1996-2008 [J].

Huang, C. -T. ;

Chen, C. -Y. ;

Chen, H. -Y. ;

Chou, C. -H. ;

Ruan, S. -Y. ;

Lai, C. -C. ;

Hsueh, P. -R. .

CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (10) :1585-1590

[8] Disseminated Mycobacterium avium complex infection in a patient carrying autoantibody to interferon-γ [J].

Ishii, Takashi ;

Tamura, Atsuhisa ;

Matsui, Hirotoshi ;

Nagai, Hideaki ;

Akagawa, Shinobu ;

Hebisawa, Akira ;

Ohta, Ken .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2013, 19 (06) :1152-1157

[9] Disseminated Mycobacterium kansasii infection with hepatic abscesses in a renal transplant recipient [J].

Kaur, P. ;

Fishman, J. A. ;

Misdraji, J. ;

Varma, M. C. ;

Kotton, C. N. .

TRANSPLANT INFECTIOUS DISEASE, 2011, 13 (05) :531-535

[10]

Kulchavenya E, 2012, MYCOBAC DIS 2012

← 1 2 →