Role of the CNS microvascular pericyte in the blood-brain barrier

被引：4

作者：

Balabanov, R ^{[1
]}

Dore-Duffy, P ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Neurol, Div Neuroimmunol, Detroit, MI 48201 USA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1998年 / 53卷 / 06期

关键词：

angiogenesis; blood-brain barrier; endothelial cells; central nervous system; macrophage; microvasculature; pericyte;

D O I：

10.1002/(SICI)1097-4547(19980915)53:6<637::AID-JNR1>3.0.CO;2-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pericytes are a very important cellular constituent of the blood-brain barrier. They play a regulatory role in brain angiogenesis, endothelial cell tight junction formation, blood-brain barrier differentiation, as well as contribute to the microvascular vasodynamic capacity and structural stability, Central nervous system pericytes express macrophage functions and are actively involved in the neuroimmune network operating at the blood-brain barrier. They exhibit unique functional characteristics critical for the pathogenesis of a number of cerebrovascular, neurodegenerative, and neuroimmune diseases. (C) 1998 Wiley-Liss, Inc.

引用

页码：637 / 644

页数：8

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