A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy

被引：16

作者：

Xiang, Menghua ^{[1
]}

Wang, Xuan ^{[1
]}

Li, Mengchu ^{[1
]}

Jia, Yan ^{[1
]}

Li, Shaoyun ^{[1
]}

Yang, Fen ^{[1
]}

Wang, Wei ^{[1
]}

Chen, Tongkai ^{[3
]}

Xu, Xiaojun ^{[4
]}

Sharma, Bigyan ^{[1
]}

Nie, Yichu ^{[1
]}

Xiao, Qicai ^{[1
,2
]}

Gao, Liqian ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China

[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[3] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510405, Peoples R China

[4] Inst Chem Biol, Shenzhen Bay Lab, Shenzhen 518107, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 31期

基金：

中国国家自然科学基金;

关键词：

Photodynamic therapy; photosensitizers; reactive oxygen species (ROS); light source; oncotherapy; targeting; GRAPHITIC-C3N4 QUANTUM DOTS; NEAR-INFRARED LIGHT; LOW-LEVEL LASER; CANCER-CELLS; 5-AMINOLEVULINIC ACID; INDOCYANINE GREEN; PORFIMER SODIUM; VITAMIN-D; DRUG; PHOTOSENSITIZERS;

D O I：

10.2174/0929867328666210121122106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic Therapy (PDT), as a clinically approved modality for the treatment of various disordered diseases including cancer, has received great advances in recent years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local irradiation by a light source with appropriate wavelength, PDT works in a dual -selective manner. Over the past decades, numerous studies and reviews on PDT mainly focused on activable PSs and the newly emerging PSs in PDT. However, to the best of our knowledge, there are few articles on the systematic introduction of light sources and limited reports about targeted strategies in PDT. This review comprehensively summarizes various light sources applied in PDT together with typical enhanced targeting strategies, and outlines their advantages and disadvantages, respectively. The clinical applications and future perspectives in light sources are also partly presented and discussed.

引用

页码：6437 / 6457

页数：21

共 134 条

[1] New photosensitizers for photodynamic therapy
Abrahamse, Heidi
Hamblin, Michael R.
[J]. BIOCHEMICAL JOURNAL, 2016, 473 : 347 - 364
[2] Ackroyd R, 2001, PHOTOCHEM PHOTOBIOL, V74, P656, DOI 10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO
[3] 2
[4] Photodynamic Therapy of Cancer: An Update
Agostinis, Patrizia
Berg, Kristian
Cengel, Keith A.
Foster, Thomas H.
Girotti, Albert W.
Gollnick, Sandra O.
Hahn, Stephen M.
Hamblin, Michael R.
Juzeniene, Asta
Kessel, David
Korbelik, Mladen
Moan, Johan
Mroz, Pawel
Nowis, Dominika
Piette, Jacques
Wilson, Brian C.
Golab, Jakub
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) : 250 - 281
[5] Allison Ron R, 2006, Future Oncol, V2, P53, DOI 10.2217/14796694.2.1.53
[6] Oncologic photodynamic therapy photosensitizers: A clinical review
Allison, Ron R.
Sibata, Claudio H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) : 61 - 75
[7] Application of Porphyrins in Antibacterial Photodynamic Therapy
Amos-Tautua, Bamidele M.
Songca, Sandile P.
Oluwafemi, Oluwatobi S.
[J]. MOLECULES, 2019, 24 (13):
[8] Silicon photosensitizers in cancer therapy: Theoretical studies on novel 5-methoxypsoralens
Ayoubi-Chianeh, Mojgan
Kassaee, Mohamad Z.
[J]. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2019, 32 (12)
[9] Cleavable linkers in antibody-drug conjugates
Bargh, Jonathan D.
Isidro-Llobet, Albert
Parker, Jeremy S.
Spring, David R.
[J]. CHEMICAL SOCIETY REVIEWS, 2019, 48 (16) : 4361 - 4374
[10] Clinical development of photodynamic agents and therapeutic applications
Baskaran R.
Lee J.
Yang S.-G.
[J]. Biomaterials Research, 22 (1)

← 1 2 3 4 5 6 7 8 9 10 →