Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

被引：12

作者：

Arasi, Stefania ^{[1
]}

Mastrorilli, Carla ^{[2
,3
]}

Pecoraro, Luca ^{[4
,5
]}

Giovannini, Mattia ^{[6
]}

Mori, Francesca ^{[6
]}

Barni, Simona ^{[6
]}

Caminiti, Lucia ^{[7
]}

Castagnoli, Riccardo ^{[8
]}

Liotti, Lucia ^{[9
]}

Saretta, Francesca ^{[10
]}

Marseglia, Gian Luigi ^{[8
]}

Novembre, Elio ^{[11
]}

机构：

[1] Bambino Gesu Pediat Hosp, IRCCS, Div Allergy, Translat Res Pediat Special Area, Piazza St Onofrio 4, I-00165 Rome, Italy

[2] Univ Hosp Consortium Corp Polyclin Bari, Pediat Unit, Pediat Hosp Giovanni 23, I-70126 Bari, Italy

[3] Univ Hosp Consortium Corp Polyclin Bari, Emergency, Pediat Hosp Giovanni 23, I-70126 Bari, Italy

[4] Univ Verona, Dept Med, I-37129 Verona, Italy

[5] ASST Mantua, Pediat Unit, I-46100 Mantua, Italy

[6] Meyer Childrens Univ Hosp, Dept Pediat, Allergy Unit, I-50139 Florence, Italy

[7] AOU Policlin Gaetano Martino, Dept Pediat, Dept Human Pathol Adult & Dev Age Gaetano Barresi, Allergy Unit, I-98158 Messina, Italy

[8] Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pediat Clin, I-27100 Pavia, Italy

[9] Presidio Osped Alta Specializzaz G Salesi, AOU Osped Riuniti Ancona, Dept Pediat, I-60126 Ancona, Italy

[10] Azienda Sanit Univ Friuli Centrale, Latisana Palmanova Hosp, Pediat Dept, I-33100 Udine, Italy

[11] Univ Florence, Dept Hlth Sci, I-70126 Florence, Italy

来源：

NUTRIENTS | 2021年 / 13卷 / 05期

关键词：

allergy; anemia; cow's milk; children; immunology; non-IgE-mediated food allergy; pneumonia; pulmonary hemosiderosis; pulmonary infiltrates; IDIOPATHIC PULMONARY HEMOSIDEROSIS; COWS MILK; PRECIPITINS; DISEASE; INFANTS;

D O I：

10.3390/nu13051710

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Infants affected by Heiner syndrome (HS) display chronic upper or lower respiratory tract infections, including otitis media or pneumonia. Clinically, gastrointestinal signs and symptoms, anemia, recurrent fever and failure to thrive can be also present. Chest X-rays can show patchy infiltrates miming pneumonia. Clinical manifestations usually disappear after a milk-free diet. The pathogenetic mechanism underlying HS remains unexplained, but the formation of immune complexes and the cell-mediated reaction have been proposed. Patients usually outgrow this hypersensitivity within a few years. The aim of this review is to provide an updated overview on the current evidence on HS in children, with a critical approach on the still undefined points of this interesting disease. Finally, we propose the first structured diagnostic approach for HS.

引用

页数：12

共 25 条

[1]

Agata H, 1997, ANN ALLERG ASTHMA IM, V78, P233

[2]

Alsukhon J, 2017, ANN ALLERG ASTHMA IM, V119, pS77, DOI 10.1016/j.anai.2017.08.218

[3] IDIOPATHIC PULMONARY HAEMOSIDEROSIS TREATED WITH A MILK-FREE DIET [J].