Three-dimensional chromosome architecture and drug addiction

被引：2

作者：

Chitaman, Javed M. ^{[1
,2
]}

Fraser, Peter ^{[1
]}

Feng, Jian ^{[1
,2
]}

机构：

[1] Florida State Univ, Dept Biol Sci, 319 Stadium Dr, Tallahassee, FL 32306 USA

[2] Florida State Univ, Program Neurosci, Tallahassee, FL 32306 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2019年 / 59卷

基金：

美国国家卫生研究院;

关键词：

CHROMATIN ARCHITECTURE; GENOME ARCHITECTURE; ORGANIZATION; MECHANISMS; GENE; IDENTIFICATION; TRANSCRIPTION; TECHNOLOGIES; EXPRESSION; PRINCIPLES;

D O I：

10.1016/j.conb.2019.05.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aberrant gene expression underlies drug addiction. Therefore, studying the regulation of gene expression in drug addiction may provide mechanistic insights into this disease, for which there are still only limited treatments. Recently, the three-dimensional (3D) organization of linear DNA in the nucleus has been recognized as having a major influence on gene transcription. Here, we review its roles in both basic brain function and neuropsychiatric disorders, while also highlighting its emerging implications in drug addiction. Unraveling the 3D architecture of chromosomes in drug addiction is adding to our understanding of this disease and has the potential to trigger novel approaches for better diagnosis and therapy.

引用

页码：137 / 145

页数：9

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