Phytochemical profile and α-glucosidase inhibitory activity of Sardinian Hypericum scruglii and Hypericum hircinum

被引:28
作者
Mandrone, Manuela [1 ]
Scognarniglio, Monica [2 ]
Fiorentino, Antonio [3 ]
Sanna, Cinzia [4 ]
Cornioli, Luca [1 ]
Antognoni, Fabiana [5 ]
Bonvicini, Francesca [6 ]
Poli, Ferruccio [1 ]
机构
[1] Univ Bologna, Dept Pharm & Biotechnol, Via Irnerio 42, I-40126 Bologna, Italy
[2] Max Planck Inst Chem Ecol, Hans Knoll Str 8, D-07745 Jena, Germany
[3] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, Via Vivaldi 43, I-81100 Caserta, Italy
[4] Univ Cagliari, Dept Life & Environm Sci, Viale St Ignazio 13, I-09123 Cagliari, Italy
[5] Univ Bologna, Dept Sci Qual Life, Corso Augusto 237, I-47921 Rimini, Italy
[6] Univ Bologna, Dept Pharm & Biotechnol, Via Massarenti 9, I-40126 Bologna, Italy
关键词
Hypericum hircinum; Ilypericum perforatum; Hypericum scruglii; H-1 NMR profile; Fluoroglucinols; alpha-glucosidase inhibition; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; PERFORATUM; METABOLOMICS; EXTRACTS; PLANTS; L; IDENTIFICATION; ANTIOXIDANT; RATS;
D O I
10.1016/j.fitote.2017.06.020
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The phytochemical profile, antioxidant activity and a-glucosidase inhibitory activity of Hypericum scruglii Bacchetta, Brullo et Salmeri and Hypericum hircinum L. were analyzed and compared to those of the best-known Hypericum perforatum L. Samples were prepared using three different extraction methods (maceration in 70% ethanol, extraction in Me0H/phosphate buffer and decoction), the influence of which on the metabolic profile and bioactivities are discussed. H. scruglii and H. hircinum extracted in 70% ethanol strongly inhibited a-glucosidase (IC50 7.25 and 14.05 mu g/ml, respectively), which is a valuable enzymatic target for treating metabolic disorders, while H. perforatum was found to be less powerful than the other two species in all the performed biological tests. The phytochemical profile was analyzed by NMR, HPLC-DAD and HPLC-FLD, revealing remarkable differences among the species. In particular, H. scruglii, which is a species endemic to Sardinia Island (Italy), was particularly enriched in two phloroglucinol-derivatives identified by means of 2D NMR and LC/MS/ MS experiments as 3-geranyl-1-(2'-methylbutanoyl)-phloroglucinol and 3-gerany1-1-(2'-methylpropanoy1)phloroglucinol.
引用
收藏
页码:184 / 193
页数:10
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