Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT-2

被引：37

作者：

Cai, Zhengxin ^{[1
]}

Li, Songye ^{[1
]}

Zhang, Wenjie ^{[1
,2
]}

Pracitto, Richard ^{[1
]}

Wu, Xiaoai ^{[1
,2
]}

Baum, Evan ^{[1
]}

Finnema, Sjoerd J. ^{[1
]}

Holden, Daniel ^{[1
]}

Toyonaga, Takuya ^{[1
]}

Lin, Shu-fei ^{[1
]}

Lindemann, Marcel ^{[1
]}

Shirali, Anupama ^{[1
]}

Labaree, David C. ^{[1
]}

Ropchan, Jim ^{[1
]}

Nabulsi, Nabeel ^{[1
]}

Carson, Richard E. ^{[1
]}

Huang, Yiyun ^{[1
]}

机构：

[1] Yale Univ, PET Ctr, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA

[2] Sichuan Univ, West China Hosp, Dept Nucl Med, Lab Clin Nucl Med, Chengdu 610041, Sichuan, Peoples R China

来源：

ACS CHEMICAL NEUROSCIENCE | 2020年 / 11卷 / 04期

关键词：

SV2A; PET; non-human primate; Alzheimer's disease; Parkinson's disease; fluorine-18; MEDIATED RADIOFLUORINATION; BINDING CHARACTERISTICS; PROTEIN; 2A; LATE-STAGE; SV2A; LEVETIRACETAM; TRACER; FLUORINATION; ROUTE; BRAIN;

D O I：

10.1021/acschemneuro.9b00618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane glycoprotein ubiquitously expressed in presynaptic vesicles. In vivo imaging of SV2A using PET has potential applications in the diagnosis and prognosis of a variety of neuropsychiatric diseases, e.g., Alzheimer's disease, Parkinson's disease, schizophrenia, multiple sclerosis, autism, epilepsy, stroke, traumatic brain injury, post-traumatic stress disorder, depression, etc. Herein, we report the synthesis and evaluation of a new F-18-labeled SV2A PET imaging probe, [F-18]SynVesT-2, which possesses fast in vivo binding kinetics and high specific binding signals in non-human primate brain.

引用

页码：592 / 603

页数：23

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