Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer

被引：139

作者：

Bronte, Vincenzo ^{[1
,2
]}

Murray, Peter J. ^{[3
,4
]}

机构：

[1] Univ Verona, Verona Univ Hosp, I-37100 Verona, Italy

[2] Univ Verona, Dept Pathol, Immunol Sect, I-37100 Verona, Italy

[3] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

NATURE MEDICINE | 2015年 / 21卷 / 02期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; DIFFERENTIATION; POLARIZATION; RESPONSES; REVEALS;

D O I：

10.1038/nm.3794

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have suggested that manipulating the tumor-associated macrophage phenotype is a valid therapeutic approach in cancer. In turn, these studies have given some insight into the factors that polarize macrophages, thereby suggesting alternative therapeutic avenues.

引用

页码：117 / 119

页数：3

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