Immunotherapy for Malignant Glioma: Current Status and Future Directions

被引：130

作者：

Wang, Hongxiang ^{[1
]}

Xu, Tao ^{[1
]}

Huang, Qilin ^{[1
,2
]}

Jin, Weilin ^{[3
,4
]}

Chen, Juxiang ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Neurosurg, Dept Neurosurg, Shanghai 200003, Peoples R China

[2] Gen Hosp Cent Theater Command Chinese Peoples Lib, Dept Neurosurg, Wuhan 430070, Peoples R China

[3] Shanghai Jiao Tong Univ, Inst Nano Biomed & Engn, Key Lab Thin Film & Microfabricat Technol, Minist Educ,Dept Instrument Sci & Engn,Sch Elect, Shanghai 200240, Peoples R China

[4] Guilin Med Univ, Affiliated Hosp, Ctr Translat Med, Guilin 541004, Peoples R China

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 02期

基金：

中国国家自然科学基金;

关键词：

LONG-TERM SURVIVAL; T-CELLS; MACROPHAGE POLARIZATION; TUMOR MICROENVIRONMENT; CHECKPOINT BLOCKADE; MISMATCH REPAIR; STEM-CELLS; GLIOBLASTOMA; TEMOZOLOMIDE; COMBINATION;

D O I：

10.1016/j.tips.2019.12.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glioma is the most common intracranial primary malignancy, with limited treatment options and a poor overall survival (OS). Immunotherapy has been used successfully in various cancers, leading to the development of similar therapies that activate the patient's immune system to eliminate glioma. In this review, we introduce the diverse immunotherapeutic approaches available for treating glioma, highlighting the successes and challenges resulting from current clinical trials. Additionally, we emphasize the effect of multiple clinical factors on immunotherapy to help optimize individualized treatment regimens. Finally, we also highlight several novel concepts and technologies that could be used to design new and/or improve existing immunotherapies. Such approaches will delineate a new blueprint for glioma treatment.

引用

页码：123 / 138

页数：16

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