Nickel-Catalyzed C(sp3)-C(sp3) Cross-Electrophile Coupling of InSitu Generated NHP Esters with Unactivated Alkyl Bromides

被引：36

作者：

Kang, Kai ^{[1
]}

Weix, Daniel J. ^{[1
]}

机构：

[1] Univ Wisconsin, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 15期

关键词：

REDOX-ACTIVE ESTERS; HALIDES; OXIDATION; DECARBOXYLATION; NI;

D O I：

10.1021/acs.orglett.2c00805

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formation of C(sp3)-C(sp3) bonds by cross-coupling remains a challenge in synthesis. Here, we demonstrate atwo-step, one-pot protocol for the in situ generation ofN-hydroxyphthalimide esters and their nickel-catalyzed cross-electrophilecoupling with unactivated alkyl bromides for the construction of 1 degrees/1 degrees C(sp3)-C(sp3) bonds. The conditions tolerate an array of functionalgroups, and mechanistic studies indicate that both substrates areconverted to alkyl radicals during the reaction.

引用

收藏

页码：2853 / 2857

页数：5

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