Cerebrospinal Fluid Real-Time Quaking-Induced Conversion Is a Robust and Reliable Test for Sporadic Creutzfeldt-Jakob Disease: An International Study

被引：82

作者：

McGuire, Lynne I. ^{[1
]}

Poleggi, Anna ^{[2
]}

Poggiolini, Ilaria ^{[3
]}

Suardi, Silvia ^{[4
]}

Grznarova, Katarina ^{[5
,6
]}

Shi, Song ^{[7
]}

de Vil, Bart ^{[8
,9
]}

Sarros, Shannon ^{[10
]}

Satoh, Katsuya ^{[11
]}

Cheng, Keding ^{[12
]}

Cramm, Maria ^{[13
,14
]}

Fairfoul, Graham ^{[1
]}

Schmitz, Matthias ^{[13
,14
]}

Zerr, Inga ^{[13
,14
]}

Cras, Patrick ^{[8
,9
]}

Equestre, Michele ^{[2
]}

Tagliavini, Fabrizio ^{[4
]}

Atarashi, Ryuichiro ^{[11
]}

Knox, David ^{[12
]}

Collins, Steven ^{[15
]}

Haik, Stephane ^{[6
,16
]}

Parchi, Piero ^{[3
,17
]}

Pocchiari, Maurizio ^{[2
]}

Green, Alison ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Natl CJD Res & Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Natl Inst Hlth, Dept Neurol Sci, Rome, Italy

[3] Sci Inst Res Hospitalizat & Hlth Care, Inst Neurol Sci, Bologna, Italy

[4] Ist Nazl Neurol Carlo Besta, Sci Inst Res Hospitalizat & Hlth Care, Dept Neurodegenerat Dis, Milan, Italy

[5] Univ Paris 06, Sorbonne Univ, Brain & Spine Inst, Paris, France

[6] Natl Reference Ctr Unconvent Transmissible Agents, Paris, France

[7] Univ Munich, Ctr Neuropathol & Prion Res, Munich, Germany

[8] Univ Antwerp, Dept Neurol, Inst Born Bunge, Antwerp, Belgium

[9] Univ Antwerp, Inst Born Bunge, Antwerp, Belgium

[10] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[11] Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Nagasaki, Japan

[12] Publ Hlth Agcy Canada, Prion Lab Sect, Winnipeg, MB, Canada

[13] Univ Gottingen, Univ Med Ctr, Dept Neurol, Gottingen, Germany

[14] Univ Gottingen, German Ctr Neurodegenerat Dis, Gottingen, Germany

[15] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[16] Hop La Pitie Salpetriere, AP HP, Paris, France

[17] Univ Bologna, Dept Biomed & Neuromotor Sci, I-40126 Bologna, Italy

来源：

ANNALS OF NEUROLOGY | 2016年 / 80卷 / 01期

关键词：

DIAGNOSTIC-CRITERIA; PRION DETECTION;

D O I：

10.1002/ana.24679

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice.

引用

页码：160 / 165

页数：6

共 10 条

[1]

[Anonymous], 1998, REPORT WHO CONSULTAT

[2] Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking [J].

Atarashi, Ryuichiro ;

Wilham, Jason M. ;

Christensen, Leah ;

Hughson, Andrew G. ;

Moore, Roger A. ;

Johnson, Lisa M. ;

Onwubiko, Henry A. ;

Priola, Suzette A. ;

Caughey, Byron .

NATURE METHODS, 2008, 5 (03) :211-212

[3] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion [J].

Atarashi, Ryuichiro ;

Satoh, Katsuya ;

Sano, Kazunori ;

Fuse, Takayuki ;

Yamaguchi, Naohiro ;

Ishibashi, Daisuke ;

Matsubara, Takehiro ;

Nakagaki, Takehiro ;

Yamanaka, Hitoki ;

Shirabe, Susumu ;

Yamada, Masahito ;

Mizusawa, Hidehiro ;

Kitamoto, Tetsuyuki ;

Klug, Genevieve ;

McGlade, Amelia ;

Collins, Steven J. ;

Nishida, Noriyuki .

NATURE MEDICINE, 2011, 17 (02) :175-178

[4] The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review [J].

Chohan, G. ;

Pennington, C. ;

Mackenzie, J. M. ;

Andrews, M. ;

Everington, D. ;

Will, R. G. ;

Knight, R. S. G. ;

Green, A. J. E. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (11) :1243-1248

[5] Characteristic CSF Prion Seeding Efficiency in Humans with Prion Diseases [J].

Cramm, Maria ;

Schmitz, Matthias ;

Karch, Andre ;

Zafar, Saima ;

Varges, Daniela ;

Mitrova, Eva ;

Schroeder, Bjoern ;

Raeber, Alex ;

Kuhn, Franziska ;

Zerr, Inga .

MOLECULAR NEUROBIOLOGY, 2015, 51 (01) :396-405

[6] Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease [J].

McGuire, Lynne I. ;

Peden, Alexander H. ;

Orru, Christina D. ;

Wilham, Jason M. ;

Appleford, Nigel E. ;

Mallinson, Gary ;

Andrews, Mary ;

Head, Mark W. ;

Caughey, Byron ;

Will, Robert G. ;

Knight, Richard S. G. ;

Green, Alison J. E. .

ANNALS OF NEUROLOGY, 2012, 72 (02) :278-285

[7] Variability in Diagnosing Creutzfeldt-Jakob Disease Using Standard and Proposed Diagnostic Criteria [J].

Newey, C. R. ;

Sarwal, A. ;

Wisco, D. ;

Alam, S. ;

Lederman, R. J. .

JOURNAL OF NEUROIMAGING, 2013, 23 (01) :58-63

[8] Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion [J].

Peden, Alexander H. ;

McGuire, Lynne I. ;

Appleford, Nigel E. J. ;

Mallinson, Gary ;

Wilham, Jason M. ;

Orru, Christina D. ;

Caughey, Byron ;

Ironside, James W. ;

Knight, Richard S. ;

Will, Robert G. ;

Green, Alison J. E. ;

Head, Mark W. .

JOURNAL OF GENERAL VIROLOGY, 2012, 93 :438-449

[9] Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays [J].

Wilham, Jason M. ;

Orru, Christina D. ;

Bessen, Richard A. ;

Atarashi, Ryuichiro ;

Sano, Kazunori ;

Race, Brent ;

Meade-White, Kimberly D. ;

Taubner, Lara M. ;

Timmes, Andrew ;

Caughey, Byron .

PLOS PATHOGENS, 2010, 6 (12)

[10] Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease [J].

Zerr, I. ;

Kallenberg, K. ;

Summers, D. M. ;

Romero, C. ;

Taratuto, A. ;

Heinemann, U. ;

Breithaupt, M. ;

Varges, D. ;

Meissner, B. ;

Ladogana, A. ;

Schuur, M. ;

Haik, S. ;

Collins, S. J. ;

Jansen, Gerard H. ;

Stokin, G. B. ;

Pimentel, J. ;

Hewer, E. ;

Collie, D. ;

Smith, P. ;

Roberts, H. ;

Brandel, J. P. ;

van Duijn, C. ;

Pocchiari, M. ;

Begue, C. ;

Cras, P. ;

Will, R. G. ;

Sanchez-Juan, P. .

BRAIN, 2009, 132 :2659-2668

← 1 →