A Facile Route to Polysubstituted Indoles via Three-Component Reaction of 2-Ethynylaniline, Sulfonyl Azide, and Nitroolefin

被引：95
作者：
Chen, Zhiyuan [1 ]
Zheng, Danqing [1 ]
We, Jie [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ONE-POT SYNTHESIS; CATALYZED MULTICOMPONENT REACTION; EFFICIENT SYNTHESIS; N-SULFONYLAMIDINES; SYNTHETIC UTILITY; CASCADE REACTIONS; BICYCLIC PEPTIDE; TANDEM REACTION; RECENT PROGRESS; AMIDE SYNTHESIS;
D O I：
10.1021/ol102775s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed three-component reaction of 2-ethynylaniline, sulfonyl azide, and nitroolefin is reported. This reaction generates functionalized indoles in good yields and proceeds smoothly under mild conditions. Some hits as an HCT-116 inhibitor are found from the preliminary biological screening.
引用
收藏
页码：848 / 851
页数：4
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