Soluble BAFF Cytokine Levels and Antibody-Mediated Rejection of the Kidney Allograft

被引:10
作者
Slavcev, Antonij [1 ]
Brozova, Jitka [1 ]
Slatinska, Janka [2 ]
Sekerkova, Zuzana [1 ]
Honsova, Eva [3 ]
Skibova, Jelena [4 ]
Striz, Ilja [5 ]
Viklicky, Ondrej [2 ]
机构
[1] Inst Clin & Expt Med, Dept Immunogenet, Videnska 1958-9, Prague 14021, Czech Republic
[2] Inst Clin & Expt Med, Clin Nephrol, Videnska 1958-9, Prague 14021, Czech Republic
[3] Inst Clin & Expt Med, Dept Clin & Transplantat Pathol, Videnska 1958-9, Prague 14021, Czech Republic
[4] Inst Clin & Expt Med, Unit Med Stat, Inst Clin & Expt Med, Videnska 1958-9, Prague 14021, Czech Republic
[5] Inst Clin & Expt Med, Dept Clin & Transplantat Immunol, Videnska 1958-9, Prague 14021, Czech Republic
关键词
BAFF; Kidney transplantation; Antibody-mediated rejection; HLA; B-LYMPHOCYTE STIMULATOR; TRANSPLANTATION; ALEMTUZUMAB; BASILIXIMAB; INDUCTION; PHENOTYPE; FAMILY; CELLS; RISK; BLYS;
D O I
10.1007/s00005-016-0428-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The B-cell activating factor (BAFF) cytokine has important functions for the survival and maturation of B lymphocytes, which implies that this cytokine might play a role in the development of antibody-mediated rejection (AMR) after kidney transplantation. In our study, we compared the concentrations of the soluble BAFF cytokine in kidney graft recipients with AMR and patients without rejection with the goal of testing the hypothesis whether BAFF level measurement might be useful as a diagnostic marker of AMR. The study included a cohort of 19 high-risk patients with diagnosed AMR and 17 control patients free of rejection. BAFF was measured in all patients before transplantation, during the rejection episodes, and three months after transplantation in patients free of rejection using the Luminex technique. Before transplantation, the serum concentrations of BAFF in patients with AMR and kidney recipients without rejection did not significantly differ. After transplantation, however, BAFF levels were significantly lower in patients with AMR and also in patients with concurrent humoral and cellular rejection compared with patients without rejection (p < 0.05 and p < 0.01, respectively). No correlation was found between BAFF and the production of donor-specific antibodies (DSA) before and after transplantation. Patients experiencing AMR and simultaneous cellular and AMR had significantly lower concentrations of BAFF in comparison with patients free of rejection.
引用
收藏
页码:S47 / S53
页数:7
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