Antioxidant and cytotoxicity to liver cancer HepG2 cells in vitro of Korarima (Aframomumcorrorima (Braun) PCM Jansen) seed extracts

被引:6
作者
Dessalegn, Engeda [1 ]
Bultosa, Geremew
Haki, GulelatDesse [2 ]
Chen, F. [3 ]
Rupasinghe, H. P. Vasantha [3 ]
机构
[1] Hawassa Coll Educ, Dept Chem, Hawassa, Ethiopia
[2] Botswana Univ Agr & Nat Resource, Dept Food Sci & Technol, Gaborone, Botswana
[3] Dalhousie Univ, Fac Agr, Dept Plant Food & Environm Sci, Truro, NS, Canada
关键词
Aframomum corrorima; Antioxidant activity; cytotoxicity; cancer; Phenolic contents; ESSENTIAL OILS; ANTICANCER ACTIVITY; CORRORIMA; PLANT;
D O I
10.1080/10942912.2021.2019268
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study examined the total phenolic contents, in vitroantioxidant activity and anti-cancer effect of petroleum ether and aqueous: methanol (20:80, v/v) seed extracts of Aframomum corrorima (Ethiopian cardamom). The aqueous methanol extract contained higher total phenolic content (25 +/- 5 mg gallic acid equivalent/100 g of dried extract and total flavonoid content (19 +/- 0.4 mg quercetin equivalent/100 g of dried extract. The extract showed stronger antioxidant activity than the petroleum ether extract, EC50 = 97 +/- 4 mu g/mL in DPPH radical scavenging assay, and EC50 = 258 +/- 15 mu g/mL in ferric reducing antioxidant power assay. In the antiproliferative assay, the petroleum ether extract showed stronger (EC50 = 105 +/- 7 mu g/mL) effect than the aqueous:methanol (20:80, v/v) extract (EC50 = 282 +/- 43 mu g/mL), on hepatocellular carcinoma (HepG2) cells when incubated for 24 h. This is the initial report to demonstrate antioxidant activity and anti-cancer in vitro effect of seed extracts of A. corrorima.
引用
收藏
页码:1 / 10
页数:10
相关论文
共 50 条
[41]   Enhanced Cytotoxicity of Biomolecules Loaded Metallic Silver Nanoparticles Against Human Liver (HepG2) and Prostate (PC3) Cancer Cell Lines [J].
Prasannaraj, Govindaraj ;
Sahi, Shivendra Vikram ;
Ravikumar, Samandham ;
Venkatachalam, Perumal .
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 16 (05) :4948-4959
[42]   Cobalt iron oxide nanoparticles induce cytotoxicity and regulate the apoptotic genes through ROS in human liver cells (HepG2) [J].
Ahamed, Maqusood ;
Akhtar, Mohd Javed ;
Khan, M. A. Majeed ;
Alhadlaq, Hisham A. ;
Alshamsan, Aws .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 148 :665-673
[43]   Cytotoxicity Study of Cadmium-Selenium Quantum Dots (Cdse QDs) for Destroying the Human HepG2 Liver Cancer Cell [J].
Rahman, Mohammed M. ;
Opo, Firoz A. D. M. ;
Asiri, Abdullah M. .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2021, 17 (11) :2153-2164
[44]   Verbesina encelioides: cytotoxicity, cell cycle arrest, and oxidative DNA damage in human liver cancer (HepG2) cell line [J].
Mai M. Al-Oqail ;
Maqsood A. Siddiqui ;
Ebtesam S. Al-Sheddi ;
Quaiser Saquib ;
Javed Musarrat ;
Abdulaziz A. Al-Khedhairy ;
Nida N. Farshori .
BMC Complementary and Alternative Medicine, 16
[45]   Selenium Nanoparticles Induce Cytotoxicity and Apoptosis in Human Breast Cancer (MCF-7) and Liver (HepG2) Cell Lines [J].
Alkhudhayri, Abdulsalam A. ;
Wahab, Rizwan ;
Siddiqui, Maqsood A. ;
Ahmad, Javed .
NANOSCIENCE AND NANOTECHNOLOGY LETTERS, 2020, 12 (03) :324-330
[46]   A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells [J].
Seeland, Swen ;
Toeroek, Michael ;
Kettiger, Helene ;
Treiber, Alexander ;
Hafner, Mathias ;
Huwyler, Joerg .
TOXICOLOGY IN VITRO, 2013, 27 (03) :1109-1120
[47]   Novel antioxidant peptides identified from coix seed by molecular docking, quantum chemical calculations and invitro study in HepG2 cells [J].
Igbokwe, Chidimma Juliet ;
Feng, Yuqin ;
Louis, Hitler ;
Benjamin, Innocent ;
Quaisie, Janet ;
Duan, Yuqing ;
Tuly, Jamila A. ;
Cai, Meihong ;
Zhang, Haihua .
FOOD CHEMISTRY, 2024, 440
[48]   Metabolism of Ebracteolata Compound B Studied In Vitro with Human Liver Microsomes, HepG2 Cells, and Recombinant Human Enzymes [J].
Zhang, Xia ;
Yao, Yan ;
Lou, Yan ;
Jiang, Huidi ;
Wang, Xiaowen ;
Chai, Xiaojuan ;
Zeng, Su .
DRUG METABOLISM AND DISPOSITION, 2010, 38 (12) :2157-2165
[49]   Effect of in vitro digestion of yerba mate (Ilex paraguariensis A. St. Hil.) extract on the cellular antioxidant activity, antiproliferative activity and cytotoxicity toward HepG2 cells [J].
Bremer Boaventura, Brunna Cristina ;
de Mello Castanho Amboni, Renata Dias ;
da Silva, Edson Luiz ;
Prudencio, Elane Schwinden ;
Di Pietro, Patricia Faria ;
Malta, Luciana Gomes ;
Polinati, Renata Madureira ;
Liu, Rui Hai .
FOOD RESEARCH INTERNATIONAL, 2015, 77 :257-263
[50]   Phenolic compounds of "blue food" Porphyra haitanensis: Chemical fingerprints, antioxidant activities, and in vitro antiproliferative activities against HepG2 cells [J].
Xu, Jingwen ;
Li, Zhujia ;
Zhao, Yong .
FOOD RESEARCH INTERNATIONAL, 2022, 162