Antioxidant and cytotoxicity to liver cancer HepG2 cells in vitro of Korarima (Aframomumcorrorima (Braun) PCM Jansen) seed extracts

被引：6

作者：

Dessalegn, Engeda ^{[1
]}

Bultosa, Geremew

Haki, GulelatDesse ^{[2
]}

Chen, F. ^{[3
]}

Rupasinghe, H. P. Vasantha ^{[3
]}

机构：

[1] Hawassa Coll Educ, Dept Chem, Hawassa, Ethiopia

[2] Botswana Univ Agr & Nat Resource, Dept Food Sci & Technol, Gaborone, Botswana

[3] Dalhousie Univ, Fac Agr, Dept Plant Food & Environm Sci, Truro, NS, Canada

来源：

INTERNATIONAL JOURNAL OF FOOD PROPERTIES | 2022年 / 25卷 / 01期

关键词：

Aframomum corrorima; Antioxidant activity; cytotoxicity; cancer; Phenolic contents; ESSENTIAL OILS; ANTICANCER ACTIVITY; CORRORIMA; PLANT;

D O I：

10.1080/10942912.2021.2019268

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study examined the total phenolic contents, in vitroantioxidant activity and anti-cancer effect of petroleum ether and aqueous: methanol (20:80, v/v) seed extracts of Aframomum corrorima (Ethiopian cardamom). The aqueous methanol extract contained higher total phenolic content (25 +/- 5 mg gallic acid equivalent/100 g of dried extract and total flavonoid content (19 +/- 0.4 mg quercetin equivalent/100 g of dried extract. The extract showed stronger antioxidant activity than the petroleum ether extract, EC50 = 97 +/- 4 mu g/mL in DPPH radical scavenging assay, and EC50 = 258 +/- 15 mu g/mL in ferric reducing antioxidant power assay. In the antiproliferative assay, the petroleum ether extract showed stronger (EC50 = 105 +/- 7 mu g/mL) effect than the aqueous:methanol (20:80, v/v) extract (EC50 = 282 +/- 43 mu g/mL), on hepatocellular carcinoma (HepG2) cells when incubated for 24 h. This is the initial report to demonstrate antioxidant activity and anti-cancer in vitro effect of seed extracts of A. corrorima.

引用

页码：1 / 10

页数：10

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