Divergent Synthesis of Ketone-Fused Indoles/Pyrroles via Metal-Guided Friedel-Crafts Cyclization

被引：6
|
作者：
Luo, Hejiang [1 ]
Cao, Tongxiang [1 ]
Zhu, Shifa [1 ,2 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China
[2] China Singapore Int Joint Res Inst, Guangzhou 510555, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 41卷 / 09期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Friedel-Crafts cyclization; ketone-fused indoles/pyrroles; divergent synthesis; CATALYZED RING-EXPANSION; DECONSTRUCTIVE REORGANIZATION; ALKALOIDS; PYRROLES; INDOLES; ACTIVATION; ANNULATION; GENERATION; INHIBITORS; MIGRATION;
D O I：
10.6023/cjoc202105021
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-guided method for divergent synthesis of ketone-fused indoles/pyrroles from N-(2-alkynylaryl) lactam is described. The reaction is proposed to proceed through a regioswitchable Friedel-Crafts cyclization of acylium. The obvious advantages are wide substrate scopes, high atom economy and step economy, which have a great potential in the synthesis of structure-related bioactive compounds.
引用
收藏
页码：3521 / 3531
页数：11
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