NON-CODING RNAs IN DEVELOPMENT AND DISEASE: BACKGROUND, MECHANISMS, AND THERAPEUTIC APPROACHES

被引：1546

作者：

Beermann, Julia

Piccoli, Maria-Teresa

Viereck, Janika

Thum, Thomas ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Mol & Translat Therapeut Strategies, Carl Neuberg Str 1, D-30625 Hannover, Germany

来源：

PHYSIOLOGICAL REVIEWS | 2016年 / 96卷 / 04期

关键词：

TO-MESENCHYMAL TRANSITION; MICRORNA SIGNATURES DIFFERENTIATE; PROCESSING ENZYME DICER; CELL-MEDIATED REJECTION; X-INACTIVATION; MYOCARDIAL-INFARCTION; CARDIAC-HYPERTROPHY; NUCLEAR EXPORT; CIRCULAR RNAS; TRANSCRIPTIONAL REGULATION;

D O I：

10.1152/physrev.00041.2015

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Advances in RNA-sequencing techniques have led to the discovery of thousands of non-coding transcripts with unknown function. There are several types of non-coding linear RNAs such as microRNAs (miRNA) and long non-coding RNAs (lncRNA), as well as circular RNAs (circRNA) consisting of a closed continuous loop. This review guides the reader through important aspects of non-coding RNA biology. This includes their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system). We specifically focus on non-coding RNAs as potential therapeutic targets and diagnostic biomarkers.

引用

页码：1297 / 1325

页数：29

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